Fumarate copolymer–chitosan cross-linked scaffold directed to osteochondrogenic tissue engineering

dc.creatorLastra, María Laura
dc.creatorMolinuevo, María Silvina
dc.creatorCortizo, Ana María
dc.creatorCortizo, María Susana
dc.date2016
dc.date.accessioned2022-10-16T23:02:32Z
dc.date.available2022-10-16T23:02:32Z
dc.identifierhttps://digital.cic.gba.gob.ar/handle/11746/11326
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/4413735
dc.descriptionNatural and synthetic cross-linked polymers allow the improvement of cytocompatibility and mechanical properties of the individual polymers. In osteochondral lesions of big size it will be required the use of scaffolds to repair the lesion. In this work a borax cross-linked scaffold based on fumarate-vinyl acetate copolymer and chitosan directed to osteochondrondral tissue engineering is developed. The cross-linked scaffolds and physical blends of the polymers are analyzed in based on their morphology, glass transition temperature, and mechanical properties. In addition, the stability, degradation behavior, and the swelling kinetics are studied. The results demonstrate that the borax cross-linked scaffold exhibits hydrogel behavior with appropriated mechanical properties for bone and cartilage tissue regeneration. Bone marrow progenitor cells and primary chondrocytes are used to demonstrate its osteo- and chondrogenic properties, respectively, assessing the osteoand chondroblastic growth and maturation, without evident signs of cytotoxicity as it is evaluated in an in vitro system.
dc.formatapplication/pdf
dc.languageInglés
dc.relationdoi:10.1002/mabi.201600219
dc.relationISSN:1616-5187
dc.rightshttp://creativecommons.org/licenses/by-nc-sa/4.0/
dc.subjectCiencias Biológicas
dc.subjectFumarate-vinyl acetate copolymer
dc.subjectChitosan
dc.subjectOsteochondrondral tissue engineering
dc.titleFumarate copolymer–chitosan cross-linked scaffold directed to osteochondrogenic tissue engineering


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