dc.creatorChang, Daniel Victor
dc.creatorTeper, Alejandro Manuel
dc.creatorBalinotti, Juan Emilio
dc.creatorCastro Simonelli, Christian
dc.creatorGarcia Bournissen, Facundo
dc.creatorKofman, Carlos
dc.date.accessioned2021-02-22T15:48:28Z
dc.date.accessioned2022-10-15T16:44:57Z
dc.date.available2021-02-22T15:48:28Z
dc.date.available2022-10-15T16:44:57Z
dc.date.created2021-02-22T15:48:28Z
dc.date.issued2019-05-27
dc.identifierChang, Daniel Victor; Teper, Alejandro Manuel; Balinotti, Juan Emilio; Castro Simonelli, Christian; Garcia Bournissen, Facundo; et al.; Exhaled nitric oxide predicts loss of asthma control in children after inhaled corticosteroids withdrawal; Veterinary and Human Toxicology; Pediatric Pulmonology; 54; 5; 27-5-2019; 537-543
dc.identifier8755-6863
dc.identifierhttp://hdl.handle.net/11336/126235
dc.identifierCONICET Digital
dc.identifierCONICET
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/4410983
dc.description.abstractBackground: Exhaled nitric oxide (eNO) has been proposed for monitoring airway inflammation, diagnosis, and prediction of steroid responsiveness in asthma. However, its utility after elective suspension of asthma medication is still unclear. We aimed to determine the association between eNO values and the subsequent loss of asthma control (LAC) in asymptomatic asthmatic children after inhaled corticosteroids (ICS) withdrawal. Methods: We conducted a prospective observational cohort study. Forty-two children (23 boys), mean age 11 years, with clinically controlled asthma, according to GINA guidelines, and receiving low-dose of ICS (budesonide 200 μg/day or equivalent) were included immediately after the withdrawal of ICS. eNO, Asthma Control Test (ACT) and spirometry were monthly assessed, during 54 weeks or until the presence of at least one of the following criteria of LAC: 1) asthma exacerbation, 2) obstructive spirometric pattern, 3) ACT ≤ 19. Results: eNO baseline geometric mean (eNO b ), measured 4 weeks after discontinuation of ICS, was 23.7 ppb (SD: 1.16). An eNO b cutoff point of 21.8 ppb was determined to better discriminate between high and low eNO groups. Twenty-five subjects (71.4%) had LAC. High eNO b was associated to LAC (OR: 9.01; 95CI: 1.10-74.26). In addition, LAC occurred earlier in high eNO b than in low eNO b patients (8 vs 28 weeks, respectively; P = 0.017). Conclusions: Our findings suggest that eNO predicts loss of asthma control and may contribute for clinical follow up decisions during childhood asthma after ICS withdrawal.
dc.languageeng
dc.publisherVeterinary and Human Toxicology
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1002/ppul.24268
dc.relationinfo:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1002/ppul.24268
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectASTHMA
dc.subjectEXHALED NITRIC OXIDE
dc.subjectINHALED CORTICOSTEROIDS
dc.titleExhaled nitric oxide predicts loss of asthma control in children after inhaled corticosteroids withdrawal
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:ar-repo/semantics/artículo
dc.typeinfo:eu-repo/semantics/publishedVersion


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