dc.creatorAgazzi, Maximiliano Luis
dc.creatorBallatore, María Belén
dc.creatorDurantini, Andres Matías
dc.creatorDurantini, Edgardo Néstor
dc.creatorTomé, Augusto C.
dc.date.accessioned2020-11-19T19:44:53Z
dc.date.accessioned2022-10-15T15:55:55Z
dc.date.available2020-11-19T19:44:53Z
dc.date.available2022-10-15T15:55:55Z
dc.date.created2020-11-19T19:44:53Z
dc.date.issued2019-09
dc.identifierAgazzi, Maximiliano Luis; Ballatore, María Belén; Durantini, Andres Matías; Durantini, Edgardo Néstor; Tomé, Augusto C.; BODIPYs in antitumoral and antimicrobial photodynamic therapy: An integrating review; Elsevier Science; Journal Of Photochemistry And Photobiology C-photochemistry Reviews; 40; 9-2019; 21-48
dc.identifier1389-5567
dc.identifierhttp://hdl.handle.net/11336/118679
dc.identifierCONICET Digital
dc.identifierCONICET
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/4405748
dc.description.abstractNowadays, both cancer and infections caused by antibiotic resistant microorganisms are problems that affect the entire planet. Phototherapy (namely photodynamic therapy (PDT) and photodynamic inactivation (PDI) of microorganisms) are an alternative method for the treatment of these diseases. That requires adequate photosensitizers and, in this sense, boron-dipyrromethenes (BODIPYs) have interesting properties to act as phototherapeutic agents. In the present review, first, we describe the different strategies used to increase reactive oxygen species production. Then, we explain different architectures developed aiming to enhance the solubility of BODIPYs in biological media in order to optimize their targeting and delivery into the cells to be treated. Finally, we discuss the design of BODIPYs that are activated by specific stimuli present in the target tissues, allowing increasing the selectivity of the treatment. The data presented and discussed here show that BODIPYs are outstanding photosensitizers for the treatment of tumors and infections in the presence of oxygen and light.
dc.languageeng
dc.publisherElsevier Science
dc.relationinfo:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S1389556718301308
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1016/j.jphotochemrev.2019.04.001
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectANTIMICROBIAL PHOTODYNAMIC THERAPY
dc.subjectANTITUMORAL PHOTODYNAMIC THERAPY
dc.subjectBODIPY
dc.subjectPHOTOKILLING
dc.subjectPHOTOSENSITIZER
dc.titleBODIPYs in antitumoral and antimicrobial photodynamic therapy: An integrating review
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:ar-repo/semantics/artículo
dc.typeinfo:eu-repo/semantics/publishedVersion


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