Polysaccharides from Gracilaria corticata: Sulfation, chemical characterization and anti-HSV activities

dc.creatorChattopadhyay, Kausik
dc.creatorGhosh, Tuhin
dc.creatorPujol, Carlos Alberto
dc.creatorCarlucci, Maria Josefina
dc.creatorDamonte, Elsa Beatriz
dc.creatorRay, Bimalendu
dc.date.accessioned2019-09-13T16:14:56Z
dc.date.accessioned2022-10-15T15:49:23Z
dc.date.available2019-09-13T16:14:56Z
dc.date.available2022-10-15T15:49:23Z
dc.date.created2019-09-13T16:14:56Z
dc.date.issued2008-11
dc.identifierChattopadhyay, Kausik; Ghosh, Tuhin; Pujol, Carlos Alberto; Carlucci, Maria Josefina; Damonte, Elsa Beatriz; et al.; Polysaccharides from Gracilaria corticata: Sulfation, chemical characterization and anti-HSV activities; Elsevier Science; International Journal of Biological Macromolecules; 43; 4; 11-2008; 346-351
dc.identifier0141-8130
dc.identifierhttp://hdl.handle.net/11336/83538
dc.identifierCONICET Digital
dc.identifierCONICET
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/4405141
dc.description.abstractIn this study, we have analyzed water-extracted polysaccharides of Gracilaria corticata. The water extract (WE), a galactan-containing sub-fraction (F3) and their hyper sulfated derivatives (WES1, WES2, F3S1 and F3S2) had anti-HSV activity with inhibitory concentration 50% (IC50) from 1.1 to 27.4 μg/ml. Sub-fraction F3, which has a molecular mass of 30 kDa, consists of a backbone of β-(1 → 3) and α-(1 → 4)-linked-galactopyranosyl residues. This linear galactan contained Gal2Xyl1, Gal2AnGal2, Gal4 and Me-Gal3AnGal2 as oligomeric building subunits. Sulfate group was located at C-4 of (1 → 3)-linked galactopyranosyl residues of the native galactan, and appeared to be very important for the anti-herpetic activity.
dc.languageeng
dc.publisherElsevier Science
dc.relationinfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S014181300800158X
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1016/j.ijbiomac.2008.07.009
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectANTI-HSV ACTIVITY
dc.subjectGALACTAN SULFATE
dc.subjectGRACILARIA CORTICATA
dc.titlePolysaccharides from Gracilaria corticata: Sulfation, chemical characterization and anti-HSV activities
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:ar-repo/semantics/artículo
dc.typeinfo:eu-repo/semantics/publishedVersion


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