L-Tenuazonic acid, a new inhibitor of Paenibacillus Larvae

dc.creatorGallardo, Gabriela Laura
dc.creatorPenalba, Nora Liliana
dc.creatorChacana, Pablo Anibal
dc.creatorTerzolo, Horacio Raúl
dc.creatorCabrera, Gabriela Myriam
dc.date.accessioned2019-09-27T18:44:12Z
dc.date.accessioned2022-10-15T15:47:49Z
dc.date.available2019-09-27T18:44:12Z
dc.date.available2022-10-15T15:47:49Z
dc.date.created2019-09-27T18:44:12Z
dc.date.issued2004-12
dc.identifierGallardo, Gabriela Laura; Penalba, Nora Liliana; Chacana, Pablo Anibal; Terzolo, Horacio Raúl; Cabrera, Gabriela Myriam; L-Tenuazonic acid, a new inhibitor of Paenibacillus Larvae; Springer; World Journal of Microbiology; 20; 6; 12-2004; 609-612
dc.identifier0959-3993
dc.identifierhttp://hdl.handle.net/11336/84702
dc.identifierCONICET Digital
dc.identifierCONICET
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/4404973
dc.description.abstractA search for bioactive compounds, inhibitors of Paenibacillus larvae, the causal agent of American foulbrood, a honeybees' disease, was carried on. Extracts of two fungal strains, Alternaria brassicicola and Alternaria raphani, isolated from pollen collected from beehives, exhibited a specific inhibitory activity against this bacterium. From these extracts and by means of chromatographic steps and bioassay-guided fractionation, three tetramic acids were isolated. The compounds were identified by spectroscopic methods and the absolute stereochemistry was chemically determined. L-Tenuazonic acid was shown to be responsible for the antibiotic activity. This compound showed a MIC of 32 μg/ml, comparable with that of oxytetracycline, an antibiotic currently used for the prevention of American foulbrood.
dc.languageeng
dc.publisherSpringer
dc.relationinfo:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1023/B:WIBI.0000043175.23621.8c
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1023/B:WIBI.0000043175.23621.8c
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectALTERNARIA BRASSICICOLA
dc.subjectALTERNARIA RAPHANI
dc.subjectAMERICAN FOULBROOD
dc.subjectL-TENUAZONIC ACID
dc.subjectPAENIBACILLUS LARVAE
dc.subjectTETRAMIC ACIDS
dc.titleL-Tenuazonic acid, a new inhibitor of Paenibacillus Larvae
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:ar-repo/semantics/artículo
dc.typeinfo:eu-repo/semantics/publishedVersion


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