dc.creatorEldholm, Vegard
dc.creatorRieux, Adrien
dc.creatorMonteserin, Johana
dc.creatorMontana Lopez, Juliana
dc.creatorPalmero, Domingo
dc.creatorLópez, Beatriz Graciela
dc.creatorRitacco, Gloria Viviana
dc.creatorDidelot, Xavier
dc.creatorBalloux, Francois
dc.date.accessioned2020-09-30T14:05:41Z
dc.date.accessioned2022-10-15T15:47:45Z
dc.date.available2020-09-30T14:05:41Z
dc.date.available2022-10-15T15:47:45Z
dc.date.created2020-09-30T14:05:41Z
dc.date.issued2016-08
dc.identifierEldholm, Vegard; Rieux, Adrien; Monteserin, Johana; Montana Lopez, Juliana; Palmero, Domingo; et al.; Impact of HIV co-infection on the evolution and transmission of multidrug-resistant tuberculosis; eLife Sciences Publications; eLife; 5; 8-2016; 1-19
dc.identifier2050-084X
dc.identifierhttp://hdl.handle.net/11336/115167
dc.identifierCONICET Digital
dc.identifierCONICET
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/4404965
dc.description.abstractThe tuberculosis (TB) epidemic is fueled by a parallel Human Immunodeficiency Virus (HIV) epidemic, but it remains unclear to what extent the HIV epidemic has been a driver for drug resistance in Mycobacterium tuberculosis (Mtb). Here we assess the impact of HIV co-infection on the emergence of resistance and transmission of Mtb in the largest outbreak of multidrug-resistant TB in South America to date. By combining Bayesian evolutionary analyses and the reconstruction of transmission networks utilizing a new model optimized for TB, we find that HIV co-infection does not significantly affect the transmissibility or the mutation rate of Mtb within patients and was not associated with increased emergence of resistance within patients. Our results indicate that the HIV epidemic serves as an amplifier of TB outbreaks by providing a reservoir of susceptible hosts, but that HIV co-infection is not a direct driver for the emergence and transmission of resistant strains.
dc.languageeng
dc.publishereLife Sciences Publications
dc.relationinfo:eu-repo/semantics/altIdentifier/url/https://elifesciences.org/articles/16644
dc.relationinfo:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4978521/
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.7554/eLife.16644
dc.rightshttps://creativecommons.org/licenses/by/2.5/ar/
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectHIV
dc.subjectMYCOBACTERIUM TUBERCULOSIS
dc.subjectANTIMICROBIAL RESISTANCE
dc.subjectEPIDEMIOLOGY
dc.subjectEVOLUTION
dc.subjectEVOLUTIONARY BIOLOGY
dc.subjectGENOMICS
dc.subjectINFECTIOUS DISEASE
dc.subjectMICROBIOLOGY
dc.subjectTRANSMISSION RECONSTRUCTION
dc.titleImpact of HIV co-infection on the evolution and transmission of multidrug-resistant tuberculosis
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:ar-repo/semantics/artículo
dc.typeinfo:eu-repo/semantics/publishedVersion


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