dc.creatorChediack, Juan Gabriel
dc.creatorCaviedes Vidal, Enrique Juan Raul
dc.creatorFasulo, Sara Veronica
dc.creatorYamin, L. J.
dc.creatorKarasov, William
dc.date.accessioned2022-06-04T02:36:22Z
dc.date.accessioned2022-10-15T15:38:42Z
dc.date.available2022-06-04T02:36:22Z
dc.date.available2022-10-15T15:38:42Z
dc.date.created2022-06-04T02:36:22Z
dc.date.issued2003-02-22
dc.identifierChediack, Juan Gabriel; Caviedes Vidal, Enrique Juan Raul; Fasulo, Sara Veronica; Yamin, L. J.; Karasov, William; Intestinal passive absorption of hydrosoluble compounds by sparrows: effect of molecular size and luminal nutrients; Springer Heidelberg; Journal of Comparative Physiology B: Biochemical, Systems and Environmental Physiology; 173; 22-2-2003; 187-197
dc.identifier0174-1578
dc.identifierhttp://hdl.handle.net/11336/158966
dc.identifier1432-136X
dc.identifierCONICET Digital
dc.identifierCONICET
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/4403996
dc.description.abstractWe tested predictions that: (1) absorption of water-soluble probes decreases with increasing molecular size, consistent with movement through effective pores in epithelia, and (2) absorption of probes is enhanced when measured in the presence of luminal nutrients, as predicted for paracellular solvent drag. Probes (L-arabinose, L-rhamnose, perseitol, lactulose; MW 150.1–342.3 Da) were gavaged in nonanesthetized House sparrows (Passer domesticus), or injected into the pectoralis, and serially measured in plasma. Bioavailability was calculated as F=AUC by gavage/AUC by injection, where AUC is the area under the curve of plasma probe concentration vs. time. Consistent with predictions, F declined with probe size by 75% from the smallest to the largest probe, and absorption of probes increased by 40% in the presence of luminal glucose or food compared to a mannitol control. Absorption of water-soluble probes by sparrows is much higher than in humans, which is much higher than in rats. These differences seem mainly attributable to differences in paracellular solvent flux and less to differences in effective paracellular pore size.
dc.languageeng
dc.publisherSpringer Heidelberg
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1007/s00360-002-0314-8
dc.relationinfo:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007/s00360-002-0314-8
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectCARBOHYDRATES
dc.subjectMODULATION
dc.subjectMOLECULAR SIEVE
dc.subjectPARACELLULAR ABSORPTION
dc.subjectSMALL INTESTINE
dc.titleIntestinal passive absorption of hydrosoluble compounds by sparrows: effect of molecular size and luminal nutrients
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:ar-repo/semantics/artículo
dc.typeinfo:eu-repo/semantics/publishedVersion


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