dc.creator | Comin, Maria Julieta | |
dc.creator | Rodriguez, Juan Bautista | |
dc.date.accessioned | 2019-10-08T19:29:40Z | |
dc.date.accessioned | 2022-10-15T15:32:50Z | |
dc.date.available | 2019-10-08T19:29:40Z | |
dc.date.available | 2022-10-15T15:32:50Z | |
dc.date.created | 2019-10-08T19:29:40Z | |
dc.date.issued | 2000-06 | |
dc.identifier | Comin, Maria Julieta; Rodriguez, Juan Bautista; First synthesis of (-)-neplanocin C; Pergamon-Elsevier Science Ltd; Tetrahedron; 56; 27; 6-2000; 4639-4649 | |
dc.identifier | 0040-4020 | |
dc.identifier | http://hdl.handle.net/11336/85365 | |
dc.identifier | CONICET Digital | |
dc.identifier | CONICET | |
dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/4403366 | |
dc.description.abstract | (-)-Neplanocin C (4), a minor component of the neplanocin family of antibiotics and a lead drug for the design of several conformationally constrained nucleosides analogues, was enantioselectively synthesized starting from D-ribono-1,4-lactone via a convergent approach in twelve steps. The proton NMR spectrum of 4 was in agreement with the corresponding natural product. Calculated coupling constants obtained from ab initio molecular modeling studies and from previously published X-ray structure of neplanocin C also corresponded to the spectroscopic data. | |
dc.language | eng | |
dc.publisher | Pergamon-Elsevier Science Ltd | |
dc.relation | info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1016/S0040-4020(00)00379-3 | |
dc.relation | info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0040402000003793 | |
dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | |
dc.rights | info:eu-repo/semantics/restrictedAccess | |
dc.subject | CARBOHYDRATES | |
dc.subject | ENANTIOMERIC PURITY | |
dc.subject | NUCLEOSIDES | |
dc.subject | PURINES | |
dc.title | First synthesis of (-)-neplanocin C | |
dc.type | info:eu-repo/semantics/article | |
dc.type | info:ar-repo/semantics/artículo | |
dc.type | info:eu-repo/semantics/publishedVersion | |