Molecular Confirmation of the Relationship between Candida guilliermondii Fks1p Naturally Occurring Amino Acid Substitutions and Its Intrinsic Reduced Echinocandin Susceptibility

dc.creatorDudiuk, Catiana Beatriz
dc.creatorMacedo, Daiana
dc.creatorLeonardelli, Florencia
dc.creatorTheill, Laura
dc.creatorCabeza, Matías Sebastián
dc.creatorGamarra, Maria Soledad
dc.creatorGarcia, Guillermo Manuel
dc.date.accessioned2018-12-11T19:47:07Z
dc.date.accessioned2022-10-15T15:29:32Z
dc.date.available2018-12-11T19:47:07Z
dc.date.available2022-10-15T15:29:32Z
dc.date.created2018-12-11T19:47:07Z
dc.date.issued2017-05
dc.identifierDudiuk, Catiana Beatriz; Macedo, Daiana; Leonardelli, Florencia; Theill, Laura; Cabeza, Matías Sebastián; et al.; Molecular Confirmation of the Relationship between Candida guilliermondii Fks1p Naturally Occurring Amino Acid Substitutions and Its Intrinsic Reduced Echinocandin Susceptibility; American Society for Microbiology; Antimicrobial Agents and Chemotherapy; 61; 5; 5-2017; 1-7
dc.identifier0066-4804
dc.identifierhttp://hdl.handle.net/11336/66294
dc.identifierCONICET Digital
dc.identifierCONICET
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/4402985
dc.description.abstractC. guilliermondii shows intrinsic reduced echinocandin susceptibility. It harbors two polymorphisms (L633M and T634A) at the Fks1p hot-spot 1 region. Our objective was to confirm that C. guilliermondii´s reduced echinocandin susceptibility is due to those naturally occurring substitutions. We constructed a Saccharomyces cerevisiae mutant where a region of its FKS1 gene (including hot-spot 1) was replaced with that from C. guilliermondii The chimeric mutants showed 32-fold echinocandin MIC values increase confirming the hypothesis.
dc.languageeng
dc.publisherAmerican Society for Microbiology
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1128/AAC.02644-16
dc.relationinfo:eu-repo/semantics/altIdentifier/url/https://aac.asm.org/content/61/5/e02644-16
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCANDIDA
dc.subjectGUILLIERMONDII
dc.subjectECHINOCANDIN
dc.subjectSUSCEPTIBILITY
dc.titleMolecular Confirmation of the Relationship between Candida guilliermondii Fks1p Naturally Occurring Amino Acid Substitutions and Its Intrinsic Reduced Echinocandin Susceptibility
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:ar-repo/semantics/artículo
dc.typeinfo:eu-repo/semantics/publishedVersion


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