dc.creatorAndreoli, Maria Florencia
dc.creatorStoker, Cora
dc.creatorRossetti, María Florencia
dc.creatorAlzamendi, Ana
dc.creatorCastrogiovanni, Daniel Cayetano
dc.creatorLuque, Enrique Hugo
dc.creatorRamos, Jorge Guillermo
dc.date.accessioned2020-04-06T18:53:49Z
dc.date.accessioned2022-10-15T15:05:10Z
dc.date.available2020-04-06T18:53:49Z
dc.date.available2022-10-15T15:05:10Z
dc.date.created2020-04-06T18:53:49Z
dc.date.issued2015-01
dc.identifierAndreoli, Maria Florencia; Stoker, Cora; Rossetti, María Florencia; Alzamendi, Ana; Castrogiovanni, Daniel Cayetano; et al.; Withdrawal of dietary phytoestrogens in adult male rats affects hypothalamic regulation of food intake, induces obesity and alters glucose metabolism; Elsevier Ireland; Molecular and Cellular Endocrinology; 401; 1-2015; 111-119
dc.identifier0303-7207
dc.identifierhttp://hdl.handle.net/11336/102064
dc.identifierCONICET Digital
dc.identifierCONICET
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/4400391
dc.description.abstractThe absence of phytoestrogens in the diet during pregnancy has been reported to result in obesity later in adulthood. We investigated whether phytoestrogen withdrawal in adult life could alter the hypothalamic signals that regulate food intake and affect body weight and glucose homeostasis. Male Wistar rats fed from conception to adulthood with a high phytoestrogen diet were submitted to phytoestrogen withdrawal by feeding a low phytoestrogen diet, or a high phytoestrogen-high fat diet. Withdrawal of dietary phytoestrogens increased body weight, adiposity and energy intake through an orexigenic hypothalamic response characterized by upregulation of AGRP and downregulation of POMC. This was associated with elevated leptin and T4, reduced TSH, testosterone and estradiol, and diminished hypothalamic ERα expression, concomitant with alterations in glucose tolerance. Removing dietary phytoestrogens caused manifestations of obesity and diabetes that were more pronounced than those induced by the high phytoestrogen-high fat diet intake.
dc.languageeng
dc.publisherElsevier Ireland
dc.relationinfo:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0303720714003955
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.mce.2014.12.002
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectPHYTOESTROGENS
dc.subjectOBESITY
dc.subjectHYPOTHALAMUS
dc.subjectGLUCOSE METABOLISM
dc.titleWithdrawal of dietary phytoestrogens in adult male rats affects hypothalamic regulation of food intake, induces obesity and alters glucose metabolism
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:ar-repo/semantics/artículo
dc.typeinfo:eu-repo/semantics/publishedVersion


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