Antiviral activity against dengue virus of diverse classes of algal sulfated polysaccharides

dc.creatorPujol, Carlos Alberto
dc.creatorRay, Sayani
dc.creatorRay, Bimalendu
dc.creatorDamonte, Elsa Beatriz
dc.date.accessioned2020-01-08T21:31:24Z
dc.date.accessioned2022-10-15T15:04:50Z
dc.date.available2020-01-08T21:31:24Z
dc.date.available2022-10-15T15:04:50Z
dc.date.created2020-01-08T21:31:24Z
dc.date.issued2012-11
dc.identifierPujol, Carlos Alberto; Ray, Sayani; Ray, Bimalendu; Damonte, Elsa Beatriz; Antiviral activity against dengue virus of diverse classes of algal sulfated polysaccharides; Elsevier Science; International Journal of Biological Macromolecules; 51; 4; 11-2012; 412-416
dc.identifier0141-8130
dc.identifierhttp://hdl.handle.net/11336/94060
dc.identifierCONICET Digital
dc.identifierCONICET
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/4400354
dc.description.abstractDiverse classes of sulfated polysaccharides obtained from the red seaweeds (Rhodophyta) Grateloupia indica, Scinaia hatei and Gracilaria corticata, the brown seaweeds (Phaeophyta) Stoechospermum marginatum and Cystoseira indica and the green seaweed (Chlorophyta) Caulerpa racemosa were assayed for antiviral activity against the four serotypes of dengue virus (DENV). DENV-2 was the most susceptible serotype to all polysulfates, with inhibitory concentration 50% values in the range 0.12-20. μg/mL. The antiviral potency of the sulfated polysaccharides depended on the sulfate content, the position of sulfate group, the sugar composition, and the molar mass. Independently of the sugar composition, the antiviral effect was mainly exerted during DENV-2 adsorption and internalization.
dc.languageeng
dc.publisherElsevier Science
dc.relationinfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0141813012001997
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1016/j.ijbiomac.2012.05.028
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectALGAL SULFATED POLYSACCHARIDES
dc.subjectANTIVIRAL ACTIVITY
dc.subjectDENGUE VIRUS
dc.subjectSUGAR COMPOSITION
dc.titleAntiviral activity against dengue virus of diverse classes of algal sulfated polysaccharides
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:ar-repo/semantics/artículo
dc.typeinfo:eu-repo/semantics/publishedVersion


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