dc.creator | Gutiérrez, Silvina | |
dc.creator | Sosa, Liliana del Valle | |
dc.creator | Petiti, Juan Pablo | |
dc.creator | Mukdsi, Jorge Humberto | |
dc.creator | Mascanfroni, Ivan Darío | |
dc.creator | Pellizas, Claudia Gabriela | |
dc.creator | de Paul, Ana Lucia | |
dc.creator | Cambiaso, Mariana Lujan | |
dc.creator | Torres, Alicia Ines | |
dc.date.accessioned | 2020-06-26T19:07:59Z | |
dc.date.accessioned | 2022-10-15T15:03:14Z | |
dc.date.available | 2020-06-26T19:07:59Z | |
dc.date.available | 2022-10-15T15:03:14Z | |
dc.date.created | 2020-06-26T19:07:59Z | |
dc.date.issued | 2012-05 | |
dc.identifier | Gutiérrez, Silvina; Sosa, Liliana del Valle; Petiti, Juan Pablo; Mukdsi, Jorge Humberto; Mascanfroni, Ivan Darío; et al.; 17β-Estradiol stimulates the translocation of endogenous estrogen receptor α at the plasma membrane of normal anterior pituitary cells; Elsevier Ireland; Molecular and Cellular Endocrinology; 355; 1; 5-2012; 169-179 | |
dc.identifier | 0303-7207 | |
dc.identifier | http://hdl.handle.net/11336/108335 | |
dc.identifier | CONICET Digital | |
dc.identifier | CONICET | |
dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/4400173 | |
dc.description.abstract | In the present work we aimed at identifying ERα in the plasma membrane of normal anterior pituitary cells and investigated if 17β-estradiol was able to induce their subcellular redistribution. Our results show that about 8% of anterior pituitary cells expressed ERα in the plasma membrane, with the geometrical mean fluorescence intensity being increased after steroid hormone treatment. 17β-Estradiol and the selective ERα agonist PPT induced an increase of ERα expression in the plasma membrane and activated the PKCα/ERK 1/2 pathway in a time-course not compatible with genomic actions, thus supporting the notion of membrane-initiated effects. These findings suggest that 17β-estradiol stimulates the translocation of endogenous ERα to the plasma membrane, consequently modulating this ER pool and leading to cellular biological effects in normal anterior pituitary gland. | |
dc.language | eng | |
dc.publisher | Elsevier Ireland | |
dc.relation | info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1016/j.mce.2012.02.008 | |
dc.relation | info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0303720712000871 | |
dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | |
dc.rights | info:eu-repo/semantics/restrictedAccess | |
dc.subject | Anterior pituitary cells | |
dc.subject | estrogen receptor alpha | |
dc.subject | 17b-estradiol | |
dc.subject | plasma membrane | |
dc.title | 17β-Estradiol stimulates the translocation of endogenous estrogen receptor α at the plasma membrane of normal anterior pituitary cells | |
dc.type | info:eu-repo/semantics/article | |
dc.type | info:ar-repo/semantics/artículo | |
dc.type | info:eu-repo/semantics/publishedVersion | |