Simultaneous improvement of ketoconazole solubility, antifungal and antibiofilm activity by multicomponent complexation

dc.creatorZoppi, Ariana
dc.creatorBartolilla, Antonela
dc.creatorLonghi, Marcela Raquel
dc.creatorAiassa, Virginia
dc.date.accessioned2021-07-27T14:47:39Z
dc.date.accessioned2022-10-15T15:00:23Z
dc.date.available2021-07-27T14:47:39Z
dc.date.available2022-10-15T15:00:23Z
dc.date.created2021-07-27T14:47:39Z
dc.date.issued2020-11
dc.identifierZoppi, Ariana; Bartolilla, Antonela; Longhi, Marcela Raquel; Aiassa, Virginia; Simultaneous improvement of ketoconazole solubility, antifungal and antibiofilm activity by multicomponent complexation; Future Medicine Ltd.; Therapeutic Delivery; 11; 11; 11-2020; 701-712
dc.identifier2041-5990
dc.identifierhttp://hdl.handle.net/11336/137052
dc.identifier2041-6008
dc.identifierCONICET Digital
dc.identifierCONICET
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/4399849
dc.description.abstractA novel multicomponent complex (MC) of ketoconazole (KET) with β-cyclodextrin (β-CD) and N-acetylcysteine (NAC) was developed with the purpose of improving the solubility as well as the antifungal and antibiofilm activity of KET against Candida albicans. Results & methodology: The interactions among the components were studied using nuclear magnetic resonance, thermal analysis, powder x-ray diffraction, infrared spectroscopy and scanning electron microscopy. Phase-solubility studies demonstrated a considerable increase in the solubility of the MC. An enhancement in antibiofilm and antifungal activity of MC was determined against C. albicans by XTT assay and microbiological studies. Conclusion: This MC, with improvements in the drug pharmaceutical performance, might have an important potential in the development of new pharmaceutical formulations of KET.
dc.languageeng
dc.publisherFuture Medicine Ltd.
dc.relationinfo:eu-repo/semantics/altIdentifier/url/https://www.future-science.com/doi/10.4155/tde-2020-0053
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.4155/tde-2020-0053
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectANTIBIOFILM ACTIVITY
dc.subjectANTIFUNGAL ACTIVITY
dc.subjectKETOCONAZOLE
dc.subjectMULTICOMPONENT COMPLEX
dc.subjectSOLUBILITY
dc.titleSimultaneous improvement of ketoconazole solubility, antifungal and antibiofilm activity by multicomponent complexation
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:ar-repo/semantics/artículo
dc.typeinfo:eu-repo/semantics/publishedVersion


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