Inhibition of Fluconazole In Vitro Antifungal Activity in Formulations Containing Propylene Glycol

dc.creatorSalerno, Claudia
dc.creatorCarlucci, Adriana Mónica
dc.creatorChiappetta, Diego Andrés
dc.creatorBregni, Carlos
dc.date.accessioned2020-09-09T20:59:28Z
dc.date.accessioned2022-10-15T14:55:09Z
dc.date.available2020-09-09T20:59:28Z
dc.date.available2022-10-15T14:55:09Z
dc.date.created2020-09-09T20:59:28Z
dc.date.issued2011-07
dc.identifierSalerno, Claudia; Carlucci, Adriana Mónica; Chiappetta, Diego Andrés; Bregni, Carlos; Inhibition of Fluconazole In Vitro Antifungal Activity in Formulations Containing Propylene Glycol; Colegio de Farmacéuticos de la Provincia de Buenos Aires; Latin American Journal of Pharmacy; 30; 7; 7-2011; 1406-1413
dc.identifier0326-2383
dc.identifierhttp://hdl.handle.net/11336/113683
dc.identifierCONICET Digital
dc.identifierCONICET
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/4399299
dc.description.abstractInhibition action of propylene glycol (PG) on the antifungal activity of fluconazole has been investigated. PG was used as cosolvent and penetration enhancer in different solutions and topical dosage forms. The interaction was analyzed by comparing with Transcutol P® (TCL), another cosolvent and penetration enhancer. Solubility of the drug was evaluated in aqueous solutions containing PG or TCL and the crystallized drug was studied by both DSC and FTIR. Solutions of the drug in the solvents were studied by FTIR and UV spectroscopy. Antifungal activity was determined for solutions with several concentrations of PG/TCL and in dosage forms with PG 10 %. Candida albicans was used as a model fungus and a procedure with standardized inoculum concentration was used. Results showed lower antifungal activity of fluconazole solutions and topical dosage forms when propylene glycol is included. Although crystallization is faster in PG solutions, solubility proved not to be the cause, but changes in FTIR spectra suggested that different hydrogen bond formation could explain the decrease in activity.
dc.languageeng
dc.publisherColegio de Farmacéuticos de la Provincia de Buenos Aires
dc.relationinfo:eu-repo/semantics/altIdentifier/url/http://www.latamjpharm.org/previous_issue.php?vol=30&num=7
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectAntifungal activity
dc.subjectFluconazole
dc.subjectHydrogen bonding
dc.subjectPropylene glycol
dc.titleInhibition of Fluconazole In Vitro Antifungal Activity in Formulations Containing Propylene Glycol
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:ar-repo/semantics/artículo
dc.typeinfo:eu-repo/semantics/publishedVersion


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