dc.creatorLerena, Maria Cecilia
dc.creatorCalligaris, Sebastián
dc.creatorColombo, Maria Isabel
dc.date.accessioned2021-03-04T20:00:28Z
dc.date.accessioned2022-10-15T14:02:02Z
dc.date.available2021-03-04T20:00:28Z
dc.date.available2022-10-15T14:02:02Z
dc.date.created2021-03-04T20:00:28Z
dc.date.issued2008-03
dc.identifierLerena, Maria Cecilia; Calligaris, Sebastián; Colombo, Maria Isabel; Autophagy: for Better or for Worse, in Good Times or in Bad Times…; Bentham Science Publishers; Current Molecular Medicine; 8; 2; 3-2008; 92-101
dc.identifier1566-5240
dc.identifierhttp://hdl.handle.net/11336/127526
dc.identifier1875-5666
dc.identifierCONICET Digital
dc.identifierCONICET
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/4394524
dc.description.abstractAutophagy is a bulk cytosolic degradative process which in the last few years has become a key pathway for the advancement of molecular medicine. Autophagy (cellular self-eating) has several implications in human disorders involving accumulation of cytosolic protein aggregatas such as Alzheimer, Parkinson, Huntington diseases, as well as in myopathies caused by deficient lysosomal functions and in cancer. Moreover, autophagy affects intracellular microorganism lifespan, acting either as a cellular defense mechanism or, on the contrary, promoting pathogen replication. Furthermore, autophagy also participates in antigen presentation, as a part of the adaptive immune response. Therefore, autophagy association with cell survival or cell death would depend on cell nutrition conditions, presence of cell intruders, and alterations in oncogene or suppressor gene expression. In this review we will focus on the wide spectra of disease-related topics where autophagy is involved, particularly, in those processes concerning microorganism infections.
dc.languageeng
dc.publisherBentham Science Publishers
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.2174/156652408783769634
dc.relationinfo:eu-repo/semantics/altIdentifier/url/https://www.eurekaselect.com/66537/article
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectATG
dc.subjectAUTOPHAGOSOME
dc.subjectHUMAN DISEASES
dc.subjectLC3
dc.titleAutophagy: for Better or for Worse, in Good Times or in Bad Times…
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:ar-repo/semantics/artículo
dc.typeinfo:eu-repo/semantics/publishedVersion


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