Maternal diabetes induces FoxO1 and connexin 43 alterations in the heart of the developing embryo

dc.creatorSato, H.
dc.creatorRoberti, Sabrina Lorena
dc.creatorMusikant, Alejandro Daniel
dc.creatorJawerbaum, Alicia Sandra
dc.creatorHiga, Romina Daniela
dc.date.accessioned2021-04-19T20:25:29Z
dc.date.accessioned2022-10-15T13:49:11Z
dc.date.available2021-04-19T20:25:29Z
dc.date.available2022-10-15T13:49:11Z
dc.date.created2021-04-19T20:25:29Z
dc.date.issued2019
dc.identifierMaternal diabetes induces FoxO1 and connexin 43 alterations in the heart of the developing embryo; International Federation of Placenta Associations; Ciudad Autónoma de Buenos Aires; Argentina; 2019; e45-e46
dc.identifier0143-4004
dc.identifierhttp://hdl.handle.net/11336/130383
dc.identifierCONICET Digital
dc.identifierCONICET
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/4393306
dc.description.abstractBackground: Maternal diabetes affects the embryonic, fetal and perinatal development and programs metabolic and cardiovascular alterations in the adult offspring. We recently reported cardiovascular alterations related to the FoxO1 pathway and in connexin43 levels in the adult offspring from diabetic rats.Both FoxO1, a transcription factor essential in nascent vascular development and connexin43, the structural subunit of gap junction and hemichannels, have important roles in cardiovascular development. Matrix metalloproteinase-2 (mmp-2) is a FoxO1 target gene that can reduce connexin43 levels. We hypothesized that there are alterations in connexin43, FoxO1 pathway and its target genes in the developing embryonic hearts of diabetic rats.
dc.languageeng
dc.publisherElsevier
dc.relationinfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0143400419302772
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1016/j.placenta.2019.06.148
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.sourcePlacenta
dc.subjectEMBRYO
dc.subjectDIABETES
dc.subjectHEART
dc.subjectFOXO1
dc.titleMaternal diabetes induces FoxO1 and connexin 43 alterations in the heart of the developing embryo
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.typeinfo:eu-repo/semantics/conferenceObject
dc.typeinfo:ar-repo/semantics/documento de conferencia


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