dc.creatorBongioanni, Agustina
dc.creatorSancho, Matias Israel
dc.creatorBueno, Maria Soledad
dc.creatorLonghi, Marcela Raquel
dc.creatorGarnero, Claudia
dc.date.accessioned2022-06-10T14:44:18Z
dc.date.accessioned2022-10-15T13:47:37Z
dc.date.available2022-06-10T14:44:18Z
dc.date.available2022-10-15T13:47:37Z
dc.date.created2022-06-10T14:44:18Z
dc.date.issued2021-10-15
dc.identifierBongioanni, Agustina; Sancho, Matias Israel; Bueno, Maria Soledad; Longhi, Marcela Raquel; Garnero, Claudia; Binary systems of albendazole desmotropes with amino-acids: Experimental and theoretical studies; Elsevier Science; Journal of Molecular Liquids; 340; 117282; 15-10-2021; 1-12
dc.identifier0167-7322
dc.identifierhttp://hdl.handle.net/11336/159472
dc.identifierCONICET Digital
dc.identifierCONICET
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/4393163
dc.description.abstractIn this work, new binary systems of albendazole desmotropes with amino-acids were developed and investigated. In particular, solubility studies evidenced that aspartic acid and glutamic acid were the most important enhancer ligands. The molecular interactions were examined by nuclear magnetic resonance and molecular modeling techniques, which revealed that the binary systems are stabilized by several intermolecular H-bonds. Solid samples were prepared by kneading method and physical mixture. It was characterized by powder X-ray diffraction, Fourier transform infrared spectroscopy, scanning electron microscopy, thermal analysis and solubility studies. The results obtained showed that the binary systems significantly incremented the saturation solubility in water and simulated gastric fluid compared to free desmotrope. In conclusion, the enhancement of biopharmaceutical properties evidenced that these novel systems are promising candidates for the development of oral formulations for delivery of the drug.
dc.languageeng
dc.publisherElsevier Science
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.molliq.2021.117282
dc.relationinfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0167732221020067
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectALBENDAZOLE
dc.subjectAMINO-ACIDS
dc.subjectDESMOTROPE
dc.subjectMOLECULAR MODELLING
dc.subjectSOLID STATE CHARACTERIZATION
dc.subjectSOLUBILITY
dc.titleBinary systems of albendazole desmotropes with amino-acids: Experimental and theoretical studies
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:ar-repo/semantics/artículo
dc.typeinfo:eu-repo/semantics/publishedVersion


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