dc.creatorOubiña, Gonzalo
dc.creatorPascuali, Natalia Marisa
dc.creatorScotti, Leopoldina
dc.creatorDi Pietro, Mariana
dc.creatorla Spina, Florenza Antonella
dc.creatorBuffone, Mariano Gabriel
dc.creatorHiguera, Javier
dc.creatorAbramovich, Dalhia Nurit
dc.creatorParborell, Maria Fernanda Agustina
dc.date.accessioned2019-10-08T19:45:56Z
dc.date.accessioned2022-10-15T13:39:49Z
dc.date.available2019-10-08T19:45:56Z
dc.date.available2022-10-15T13:39:49Z
dc.date.created2019-10-08T19:45:56Z
dc.date.issued2019-08
dc.identifierOubiña, Gonzalo; Pascuali, Natalia Marisa; Scotti, Leopoldina; Di Pietro, Mariana; la Spina, Florenza Antonella; et al.; Low level laser therapy (LLLT) modulates ovarian function in mature female mice; Pergamon-Elsevier Science Ltd; Progress In Biophysics And Molecular Biology; 145; 8-2019; 10-18
dc.identifier0079-6107
dc.identifierhttp://hdl.handle.net/11336/85373
dc.identifierCONICET Digital
dc.identifierCONICET
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/4392367
dc.description.abstractIt is known that LLLT has beneficial effects on several pathological conditions including wound healing,pain and inflammation. LLLT modulates biological processes, including cell proliferation, apoptosis andangiogenesis. In the present study, we examined the effect of local application of LLLT on follicular dynamics,ovarian reserve, AMH expression, progesterone levels, apoptosis, angiogenesis, and reproductiveoutcome in adult mice. LLLT (200 J/cm2) increased the percentage of primary and preantral follicles,whilst decreasing the percentage of corpora lutea compared to control ovaries. LLLT-treated ovaries didnot exhibit any changes regarding the number of primordial follicles.We observed a higher percentage ofAMH-positive follicles (in early stages of development) in LLLT-treated ovaries compared to controlovaries. LLLT reduced the P4 concentration and the apoptosis in early antral follicles compared to controlones. LLLT caused a reduction in the endothelial cell area and an increase in the periendothelial cell areain the ovary. Additionally, LLLT was able to improve oocyte quality. Our findings suggest that localapplication of LLLT modulates follicular dynamics by regulating apoptosis and the vascular stability inmouse ovary. In conclusion, these data indicate that LLLT might become a novel and useful tool in thetreatment of several pathologies, including female reproductive disorders.
dc.languageeng
dc.publisherPergamon-Elsevier Science Ltd
dc.relationinfo:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S0079610718301573
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.pbiomolbio.2018.11.010
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectOVARY
dc.subjectLOW LEVEL LASER THERAPY
dc.subjectFOLLICULOGENESIS
dc.subjectAPOPTOSIS
dc.titleLow level laser therapy (LLLT) modulates ovarian function in mature female mice
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:ar-repo/semantics/artículo
dc.typeinfo:eu-repo/semantics/publishedVersion


Este ítem pertenece a la siguiente institución