Involvement of SARA in axon and dendrite growth

dc.creatorArias, Cristina Isabel
dc.creatorSiri, Sebastian Omar
dc.creatorConde, Cecilia Beatriz
dc.date.accessioned2019-02-05T14:57:43Z
dc.date.accessioned2022-10-15T13:35:57Z
dc.date.available2019-02-05T14:57:43Z
dc.date.available2022-10-15T13:35:57Z
dc.date.created2019-02-05T14:57:43Z
dc.date.issued2015-09
dc.identifierArias, Cristina Isabel; Siri, Sebastian Omar; Conde, Cecilia Beatriz; Involvement of SARA in axon and dendrite growth; Public Library of Science; Plos One; 10; 9; 9-2015; 1-19
dc.identifier1932-6203
dc.identifierhttp://hdl.handle.net/11336/69401
dc.identifierCONICET Digital
dc.identifierCONICET
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/4391989
dc.description.abstractSARA (Smad Anchor for Receptor Activation) plays a crucial role in Rab5-mediated endocytosis in cell lines localizing to early endosomes where it regulates morphology and function. Here, we analyzed the role of SARA during neuronal development and tested whether it functions as a regulator of endocytic trafficking of selected axonal and membrane proteins. Suppression of SARA perturbs the appearance of juxtanuclear endocytic recycling compartments and the neurons show long axons with large growth cones. Furthermore, surface distribution of the cell adhesion molecule L1 in axons and the fusion of vesicles containing transferring receptor (TfR) in dendrites were increased in neurons where SARA was silenced. Conversely, SARA overexpression generated large early endosomes and reduced neurite outgrowth. Taken together, our findings suggest a significant contribution of SARA to key aspects of neuronal development, including neurite formation. Copyright:
dc.languageeng
dc.publisherPublic Library of Science
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1371/journal.pone.0138792
dc.relationinfo:eu-repo/semantics/altIdentifier/url/https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0138792
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAXON
dc.subjectDENDRITE
dc.subjectPOLARITY
dc.subjectENDOSOMES
dc.titleInvolvement of SARA in axon and dendrite growth
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:ar-repo/semantics/artículo
dc.typeinfo:eu-repo/semantics/publishedVersion


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