dc.creatorPodaza, Enrique Arturo
dc.creatorPalacios, Florencia
dc.creatorCroci Russo, Diego Omar
dc.creatorRisnik, Denise Mariel
dc.creatorYan, Xiao J.
dc.creatorAlmejún, María Belén
dc.creatorColado, Ana
dc.creatorElías, Esteban Enrique
dc.creatorBorge, Mercedes
dc.creatorMorande, Pablo Elías
dc.creatorBezares, Raimundo F.
dc.creatorFernández Grecco, Horacio
dc.creatorRabinovich, Gabriel Adrián
dc.creatorGamberale, Romina
dc.creatorChiorazzi, Nicholas
dc.creatorGiordano, Mirta Nilda
dc.date.accessioned2020-06-30T15:16:01Z
dc.date.accessioned2022-10-15T13:28:56Z
dc.date.available2020-06-30T15:16:01Z
dc.date.available2022-10-15T13:28:56Z
dc.date.created2020-06-30T15:16:01Z
dc.date.issued2020-01
dc.identifierPodaza, Enrique Arturo; Palacios, Florencia; Croci Russo, Diego Omar; Risnik, Denise Mariel; Yan, Xiao J.; et al.; Expression and function of cathelicidin hCAP18/LL-37 in chronic lymphocytic leukemia; Ferrata Storti Foundation; Haematologica; 2020; 1-2020; 1-25
dc.identifier0390-6078
dc.identifierhttp://hdl.handle.net/11336/108505
dc.identifier1592-8721
dc.identifierCONICET Digital
dc.identifierCONICET
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/4391416
dc.description.abstractChronic lymphocytic leukemia (CLL) is characterized by the accumulation of clonal Bcellsin peripheral blood and lymphoid tissues 1. Circulating CLL cells are non-dividing Blymphocytes, but a significant fraction of the clone proliferates in lymphoid tissues wherethey receive a plethora of signals from the microenvironment that promote their survivaland expansion 2. Cathelicidins are a family of proteins with antibacterial functions mainlyexpressed by neutrophils, macrophages and epithelial cells 3. In humans, the only memberof this family, hCAP18, is encoded by the gene CAMP. The cleavage of hCAP18 generatesthe antimicrobial peptide LL-37, which has been recently implicated in the promotion oftumor growth, through direct stimulation of malignant cells, initiation of angiogenesis andrecruitment of immune cells 4. In this study, we investigated the role of hCAP18/LL-37 inCLL.
dc.languageeng
dc.publisherFerrata Storti Foundation
dc.relationinfo:eu-repo/semantics/altIdentifier/url/http://www.haematologica.org/lookup/doi/10.3324/haematol.2019.227975
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3324/haematol.2019.227975
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectABT-199
dc.subjectCHRONIC LYMPHOCYTIC LEUKEMIA
dc.subjectMICROENVIRONMENT
dc.subjectHCAP18/LL-37
dc.titleExpression and function of cathelicidin hCAP18/LL-37 in chronic lymphocytic leukemia
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:ar-repo/semantics/artículo
dc.typeinfo:eu-repo/semantics/publishedVersion


Este ítem pertenece a la siguiente institución