dc.creator | Podaza, Enrique Arturo | |
dc.creator | Palacios, Florencia | |
dc.creator | Croci Russo, Diego Omar | |
dc.creator | Risnik, Denise Mariel | |
dc.creator | Yan, Xiao J. | |
dc.creator | Almejún, María Belén | |
dc.creator | Colado, Ana | |
dc.creator | Elías, Esteban Enrique | |
dc.creator | Borge, Mercedes | |
dc.creator | Morande, Pablo Elías | |
dc.creator | Bezares, Raimundo F. | |
dc.creator | Fernández Grecco, Horacio | |
dc.creator | Rabinovich, Gabriel Adrián | |
dc.creator | Gamberale, Romina | |
dc.creator | Chiorazzi, Nicholas | |
dc.creator | Giordano, Mirta Nilda | |
dc.date.accessioned | 2020-06-30T15:16:01Z | |
dc.date.accessioned | 2022-10-15T13:28:56Z | |
dc.date.available | 2020-06-30T15:16:01Z | |
dc.date.available | 2022-10-15T13:28:56Z | |
dc.date.created | 2020-06-30T15:16:01Z | |
dc.date.issued | 2020-01 | |
dc.identifier | Podaza, Enrique Arturo; Palacios, Florencia; Croci Russo, Diego Omar; Risnik, Denise Mariel; Yan, Xiao J.; et al.; Expression and function of cathelicidin hCAP18/LL-37 in chronic lymphocytic leukemia; Ferrata Storti Foundation; Haematologica; 2020; 1-2020; 1-25 | |
dc.identifier | 0390-6078 | |
dc.identifier | http://hdl.handle.net/11336/108505 | |
dc.identifier | 1592-8721 | |
dc.identifier | CONICET Digital | |
dc.identifier | CONICET | |
dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/4391416 | |
dc.description.abstract | Chronic lymphocytic leukemia (CLL) is characterized by the accumulation of clonal Bcellsin peripheral blood and lymphoid tissues 1. Circulating CLL cells are non-dividing Blymphocytes, but a significant fraction of the clone proliferates in lymphoid tissues wherethey receive a plethora of signals from the microenvironment that promote their survivaland expansion 2. Cathelicidins are a family of proteins with antibacterial functions mainlyexpressed by neutrophils, macrophages and epithelial cells 3. In humans, the only memberof this family, hCAP18, is encoded by the gene CAMP. The cleavage of hCAP18 generatesthe antimicrobial peptide LL-37, which has been recently implicated in the promotion oftumor growth, through direct stimulation of malignant cells, initiation of angiogenesis andrecruitment of immune cells 4. In this study, we investigated the role of hCAP18/LL-37 inCLL. | |
dc.language | eng | |
dc.publisher | Ferrata Storti Foundation | |
dc.relation | info:eu-repo/semantics/altIdentifier/url/http://www.haematologica.org/lookup/doi/10.3324/haematol.2019.227975 | |
dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3324/haematol.2019.227975 | |
dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.subject | ABT-199 | |
dc.subject | CHRONIC LYMPHOCYTIC LEUKEMIA | |
dc.subject | MICROENVIRONMENT | |
dc.subject | HCAP18/LL-37 | |
dc.title | Expression and function of cathelicidin hCAP18/LL-37 in chronic lymphocytic leukemia | |
dc.type | info:eu-repo/semantics/article | |
dc.type | info:ar-repo/semantics/artículo | |
dc.type | info:eu-repo/semantics/publishedVersion | |