dc.creator | Siri, Sebastian Omar | |
dc.creator | Martino, Julieta | |
dc.creator | Gottifredi, Vanesa | |
dc.date.accessioned | 2021-11-24T16:01:06Z | |
dc.date.accessioned | 2022-10-15T12:52:30Z | |
dc.date.available | 2021-11-24T16:01:06Z | |
dc.date.available | 2022-10-15T12:52:30Z | |
dc.date.created | 2021-11-24T16:01:06Z | |
dc.date.issued | 2021-06 | |
dc.identifier | Siri, Sebastian Omar; Martino, Julieta; Gottifredi, Vanesa; Structural chromosome instability: Types, origins, consequences, and therapeutic opportunities; Molecular Diversity Preservation International; Cancers; 13; 12; 6-2021 | |
dc.identifier | 2072-6694 | |
dc.identifier | http://hdl.handle.net/11336/147339 | |
dc.identifier | 2072-6694 | |
dc.identifier | CONICET Digital | |
dc.identifier | CONICET | |
dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/4388225 | |
dc.description.abstract | Chromosomal instability (CIN) refers to an increased rate of acquisition of numerical and structural changes in chromosomes and is considered an enabling characteristic of tumors. Given its role as a facilitator of genomic changes, CIN is increasingly being considered as a possible therapeutic target, raising the question of which variables may convert CIN into an ally instead of an enemy during cancer treatment. This review discusses the origins of structural chromosome abnormalities and the cellular mechanisms that prevent and resolve them, as well as how different CIN phenotypes relate to each other. We discuss the possible fates of cells containing structural CIN, focusing on how a few cell duplication cycles suffice to induce profound CIN-mediated genome alterations. Because such alterations can promote tumor adaptation to treatment, we discuss currently proposed strategies to either avoid CIN or enhance CIN to a level that is no longer compatible with cell survival. | |
dc.language | eng | |
dc.publisher | Molecular Diversity Preservation International | |
dc.relation | info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2072-6694/13/12/3056 | |
dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3390/cancers13123056 | |
dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.subject | CHROMOSOME ABERRATIONS | |
dc.subject | CHROMOSOME BRIDGES | |
dc.subject | CHROMOSOME INSTABILITY | |
dc.subject | DNA DAMAGE | |
dc.subject | DNA REPAIR | |
dc.subject | LAGGING CHROMO-SOMES | |
dc.subject | MICRONUCLEI | |
dc.subject | ULTRA-FINE BRIDGES | |
dc.title | Structural chromosome instability: Types, origins, consequences, and therapeutic opportunities | |
dc.type | info:eu-repo/semantics/article | |
dc.type | info:ar-repo/semantics/artículo | |
dc.type | info:eu-repo/semantics/publishedVersion | |