dc.creatorSiri, Sebastian Omar
dc.creatorMartino, Julieta
dc.creatorGottifredi, Vanesa
dc.date.accessioned2021-11-24T16:01:06Z
dc.date.accessioned2022-10-15T12:52:30Z
dc.date.available2021-11-24T16:01:06Z
dc.date.available2022-10-15T12:52:30Z
dc.date.created2021-11-24T16:01:06Z
dc.date.issued2021-06
dc.identifierSiri, Sebastian Omar; Martino, Julieta; Gottifredi, Vanesa; Structural chromosome instability: Types, origins, consequences, and therapeutic opportunities; Molecular Diversity Preservation International; Cancers; 13; 12; 6-2021
dc.identifier2072-6694
dc.identifierhttp://hdl.handle.net/11336/147339
dc.identifier2072-6694
dc.identifierCONICET Digital
dc.identifierCONICET
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/4388225
dc.description.abstractChromosomal instability (CIN) refers to an increased rate of acquisition of numerical and structural changes in chromosomes and is considered an enabling characteristic of tumors. Given its role as a facilitator of genomic changes, CIN is increasingly being considered as a possible therapeutic target, raising the question of which variables may convert CIN into an ally instead of an enemy during cancer treatment. This review discusses the origins of structural chromosome abnormalities and the cellular mechanisms that prevent and resolve them, as well as how different CIN phenotypes relate to each other. We discuss the possible fates of cells containing structural CIN, focusing on how a few cell duplication cycles suffice to induce profound CIN-mediated genome alterations. Because such alterations can promote tumor adaptation to treatment, we discuss currently proposed strategies to either avoid CIN or enhance CIN to a level that is no longer compatible with cell survival.
dc.languageeng
dc.publisherMolecular Diversity Preservation International
dc.relationinfo:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2072-6694/13/12/3056
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3390/cancers13123056
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCHROMOSOME ABERRATIONS
dc.subjectCHROMOSOME BRIDGES
dc.subjectCHROMOSOME INSTABILITY
dc.subjectDNA DAMAGE
dc.subjectDNA REPAIR
dc.subjectLAGGING CHROMO-SOMES
dc.subjectMICRONUCLEI
dc.subjectULTRA-FINE BRIDGES
dc.titleStructural chromosome instability: Types, origins, consequences, and therapeutic opportunities
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:ar-repo/semantics/artículo
dc.typeinfo:eu-repo/semantics/publishedVersion


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