Lung oxidative metabolism after exposure to ambient particles

dc.creatorMagnani, Natalia Daniela
dc.creatorMarchini, Timoteo Oscar
dc.creatorTasat, Deborah Ruth
dc.creatorAlvarez, Silvia
dc.creatorEvelson, Pablo Andrés
dc.date.accessioned2019-01-04T20:26:11Z
dc.date.accessioned2022-10-15T12:37:33Z
dc.date.available2019-01-04T20:26:11Z
dc.date.available2022-10-15T12:37:33Z
dc.date.created2019-01-04T20:26:11Z
dc.date.issued2011-09
dc.identifierMagnani, Natalia Daniela; Marchini, Timoteo Oscar; Tasat, Deborah Ruth; Alvarez, Silvia; Evelson, Pablo Andrés; Lung oxidative metabolism after exposure to ambient particles; Academic Press Inc Elsevier Science; Biochemical and Biophysical Research Communications; 412; 4; 9-2011; 667-672
dc.identifier0006-291X
dc.identifierhttp://hdl.handle.net/11336/67463
dc.identifierCONICET Digital
dc.identifierCONICET
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/4386854
dc.description.abstractThe aim of this work was to study the time course of the oxidative metabolism in mice lung after exposure to ambient particles (ROFA). Swiss mice were intranasally instilled with a ROFA suspension (0.20. mg/kg). Animals were sacrificed 1 or 3. h after the exposure. Eighty percentage of increased oxygen consumption was observed in tissue cubes after 1. h of exposure. This observation was accompanied by an increased NADPH oxidase activity (40%) and mitochondrial oxygen consumption in state 3 (19%). NO production by lung homogenates was found to be increased by 43% after 3. h of exposure. Phospholipid oxidation in lung homogenates showed a 29% increase after 1. h of exposure, while a 30% increase in the carbonyl content was found only after 3. h of exposure. Our data show the relative importance of different sources of reactive oxygen species (NADPH oxidase activity and mitochondrial respiration) to the increased tissue oxygen consumption, oxidative damage and antioxidant status observed in an acute model of ROFA particles exposure.
dc.languageeng
dc.publisherAcademic Press Inc Elsevier Science
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.bbrc.2011.08.021
dc.relationinfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0006291X11014069
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectAIR PARTICLE POLLUTANTS
dc.subjectLUNG
dc.subjectOXYGEN CONSUMPTION
dc.subjectREACTIVE OXYGEN SPECIES
dc.titleLung oxidative metabolism after exposure to ambient particles
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:ar-repo/semantics/artículo
dc.typeinfo:eu-repo/semantics/publishedVersion


Este ítem pertenece a la siguiente institución