Argentina | info:eu-repo/semantics/article
dc.creatorBermudez Moretti, Mariana
dc.creatorCorrea Garcia, Susana Raquel
dc.creatorBatlle, Alcira María del C.
dc.date.accessioned2020-03-25T21:18:42Z
dc.date.accessioned2022-10-15T12:34:13Z
dc.date.available2020-03-25T21:18:42Z
dc.date.available2022-10-15T12:34:13Z
dc.date.created2020-03-25T21:18:42Z
dc.date.issued2000-06
dc.identifierBermudez Moretti, Mariana; Correa Garcia, Susana Raquel; Batlle, Alcira María del C.; Porphyrin biosynthesis intermediates are not regulating δ-aminolevulinic acid transport in Saccharomyces cerevisiae; Academic Press Inc Elsevier Science; Biochemical and Biophysical Research Communications; 272; 3; 6-2000; 946-950
dc.identifier0006-291X
dc.identifierhttp://hdl.handle.net/11336/100834
dc.identifierCONICET Digital
dc.identifierCONICET
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/4386525
dc.description.abstractIn Saccharomyces cerevisiae, as in all eukaryotic organisms, δ-aminolevulinic acid (ALA) is a precursor of porphyrin biosynthesis, a very finely regulated pathway. ALA enters yeast cells through the γ-aminobutyric acid (GABA) permease Uga4. The incorporation of a metabolite into the cells may be a limiting step for its intracellular metabolization. To determine the relationship between ALA transport and ALA metabolization, ALA incorporation was measured in yeast mutant strains deficient in the δ-aminolevulinic acid-synthase, uroporphyrinogen III decarboxylase, and ferrochelatase, three enzymes involved in porphyrin biosynthesis. Results presented here showed that neither intracellular ALA nor uroporphyrin or protoporphyrin regulates ALA incorporation, indicating that ALA uptake and its subsequent metabolization are not related to each other. Thus a key metabolite as it is, ALA does not have a transport system regulated according to its role.
dc.languageeng
dc.publisherAcademic Press Inc Elsevier Science
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1006/bbrc.2000.2874
dc.relationinfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0006291X00928742
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectMEMBRANE TRANSPORT
dc.subjectPORPHYRIN BIOSYNTHESIS
dc.subjectSACCHAROMYCES CEREVISIAE
dc.subjectTRANSPORT REGULATION
dc.subjectUGA4 PERMEASE
dc.subjectΓ-AMINOBUTYRIC ACID
dc.subjectΔ-AMINOLEVULINIC ACID
dc.titlePorphyrin biosynthesis intermediates are not regulating δ-aminolevulinic acid transport in Saccharomyces cerevisiae
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:ar-repo/semantics/artículo
dc.typeinfo:eu-repo/semantics/publishedVersion


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