dc.creator | D'attilio, Luciano David | |
dc.creator | Díaz, Ariana | |
dc.creator | Fernández, Rocío del Valle | |
dc.creator | Bongiovanni, Bettina | |
dc.creator | Santucci, Natalia Estefanía | |
dc.creator | Dídoli, Griselda | |
dc.creator | Lioi, Susana | |
dc.creator | Gardeñez, W. | |
dc.creator | Naninni, J. L. | |
dc.creator | Del Rey, A. | |
dc.creator | Besedovsky, H. | |
dc.creator | Bottasso, Oscar Adelmo | |
dc.creator | Bay, Maria Luisa | |
dc.date.accessioned | 2019-12-10T19:17:34Z | |
dc.date.accessioned | 2022-10-15T12:10:25Z | |
dc.date.available | 2019-12-10T19:17:34Z | |
dc.date.available | 2022-10-15T12:10:25Z | |
dc.date.created | 2019-12-10T19:17:34Z | |
dc.date.issued | 2018-03 | |
dc.identifier | D'attilio, Luciano David; Díaz, Ariana; Fernández, Rocío del Valle; Bongiovanni, Bettina; Santucci, Natalia Estefanía; et al.; The neuro-endocrine-immune relationship in pulmonary and pleural tuberculosis: A better local profile in pleural fluid; International Union Against Tuberculosis and Lung Disease; International Journal of Tuberculosis and Lung Disease; 22; 3; 3-2018; 321-327 | |
dc.identifier | 1027-3719 | |
dc.identifier | http://hdl.handle.net/11336/91949 | |
dc.identifier | 1027-3719 | |
dc.identifier | CONICET Digital | |
dc.identifier | CONICET | |
dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/4384436 | |
dc.description.abstract | BACKGROUND: Tuberculosis (TB) is a major health problem worldwide. In TB, the immune and central nervous systems modulate each other. The two main components of this network are the hypothalamic-pituitary-adrenal axis (HPA) and autonomic nervous system (ANS). OBJECTIVE: To elucidate neuro-endocrine-immune (NEI) interactions in pulmonary (PTB) or pleural (PLTB) TB, we analysed the relationship among compounds from these systems. METHODS: We quantified levels of catecholamines, hormones and cytokines in plasma from patients with PTB (n = 46) or PLTB (n = 12) and controls (n = 32), and in the pleural fluid from PLTB patients. Transcript expression for genes involved in glucocorticoid-related function (quantitative real-time polymerase chain reaction) was also analysed in mononuclear cells (MCs) from peripheral blood (PBMC) or pleural effusion (PEMC) compartments. RESULTS: Both patient groups had increased plasma levels of pro- and anti-inflammatory cytokines, cortisol, growth hormone (GH) and dopamine, whereas insulin-like growth factor 1 (IGF-1) and dehydroepiandrosterone levels were decreased. The pleural fluid contained increased levels of pro-inflammatory cytokines, GH and IGF-1 and reduced levels of steroid hormones compared with their plasma counterparts. PBMCs from PTB patients had increased expression of transcripts for 11β-hydroxysteroid dehydrogenase (11βHSD1) and a decreased glucocorticoid receptor (GR) ratio (GRα/GRβ). In PLTB cases, expression of 11βHSD1 and GRα transcripts was higher in PEMCs. CONCLUSION: PTB patients seem to display adverse NEI dysregulation. Changes in pleural fluid are compatible with a more effective NEI reaction. | |
dc.language | eng | |
dc.publisher | International Union Against Tuberculosis and Lung Disease | |
dc.relation | info:eu-repo/semantics/altIdentifier/url/http://www.ingentaconnect.com/content/10.5588/ijtld.17.0270 | |
dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.5588/ijtld.17.0270 | |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ | |
dc.rights | info:eu-repo/semantics/restrictedAccess | |
dc.subject | ADRENAL STEROIDS | |
dc.subject | CYTOKINES | |
dc.subject | NEURO-ENDOCRINE-IMMUNE MODULATION | |
dc.subject | PLEURAL TUBERCULOSIS | |
dc.subject | PULMONARY TUBERCULOSIS | |
dc.title | The neuro-endocrine-immune relationship in pulmonary and pleural tuberculosis: A better local profile in pleural fluid | |
dc.type | info:eu-repo/semantics/article | |
dc.type | info:ar-repo/semantics/artículo | |
dc.type | info:eu-repo/semantics/publishedVersion | |