Precision Medicine in the Renin Angiotensin System Therapeutic Targets and Biological Variability

dc.creatorKeller, Guillermo Alberto
dc.creatorFerreiros Gago, María Laura
dc.creatorDi Salvo, Hector
dc.creatorDi Girolamo, Guillermo
dc.date.accessioned2021-04-14T12:21:31Z
dc.date.accessioned2022-10-15T12:10:22Z
dc.date.available2021-04-14T12:21:31Z
dc.date.available2022-10-15T12:10:22Z
dc.date.created2021-04-14T12:21:31Z
dc.date.issued2020-07
dc.identifierKeller, Guillermo Alberto; Ferreiros Gago, María Laura; Di Salvo, Hector; Di Girolamo, Guillermo; Precision Medicine in the Renin Angiotensin System Therapeutic Targets and Biological Variability; Bentham Science Publishers; Current Drug Targets; 21; 15; 7-2020; 1625-1637
dc.identifier1389-4501
dc.identifierhttp://hdl.handle.net/11336/130006
dc.identifierCONICET Digital
dc.identifierCONICET
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/4384431
dc.description.abstractAbstract: Pathologies linked to the renin angiotensin system are frequent, and the drugs used in them are numerous and show great variability in therapeutic effects and adverse reactions. Genetic variants have been detected in the angiotensinogen gene (6), angiotensin converting enzyme (9), Angiotensin converting enzyme 2 (1), and angiotensin receptor Type 1 (4) among others. However, the large number of studies that have analyzed each of them makes it complex and almost impossible to consider all the existing information. This manuscript aims to review the effects of the different known variants on the expected response of different drugs as a basis for the future development of therapeutic guidelines that seek to implement therapeutic individualization strategies on the renin angiotensin system.
dc.languageeng
dc.publisherBentham Science Publishers
dc.relationinfo:eu-repo/semantics/altIdentifier/url/https://www.eurekaselect.com/183881/article
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/ 10.2174/1389450121666200719010849
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectPrecision medicine
dc.subjectAldosterone
dc.subjectPopulation biological variations
dc.subjectRenin-angiotensin-aldosterone system
dc.titlePrecision Medicine in the Renin Angiotensin System Therapeutic Targets and Biological Variability
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:ar-repo/semantics/artículo
dc.typeinfo:eu-repo/semantics/publishedVersion


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