Unbalance between sarcoplasmic reticulum Ca2 + uptake and release: A first step toward Ca2 + triggered arrhythmias and cardiac damage

dc.creatorFederico, Marilén
dc.creatorValverde, Carlos Alfredo
dc.creatorMattiazzi, Ramona Alicia
dc.creatorPalomeque, Julieta
dc.date.accessioned2021-10-01T15:46:13Z
dc.date.accessioned2022-10-15T11:54:18Z
dc.date.available2021-10-01T15:46:13Z
dc.date.available2022-10-15T11:54:18Z
dc.date.created2021-10-01T15:46:13Z
dc.date.issued2020-01-23
dc.identifierFederico, Marilén; Valverde, Carlos Alfredo; Mattiazzi, Ramona Alicia; Palomeque, Julieta; Unbalance between sarcoplasmic reticulum Ca2 + uptake and release: A first step toward Ca2 + triggered arrhythmias and cardiac damage; Frontiers Media; Frontiers in Physiology; 10; 23-1-2020; 1-20
dc.identifier1664-042X
dc.identifierhttp://hdl.handle.net/11336/142252
dc.identifierCONICET Digital
dc.identifierCONICET
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/4383140
dc.description.abstractThe present review focusses on the regulation and interplay of cardiac SR Ca2+ handling proteins involved in SR Ca2+ uptake and release, i.e., SERCa2/PLN and RyR2. Both RyR2 and SERCA2a/PLN are highly regulated by post-translational modifications and/or different partners’ proteins. These control mechanisms guarantee a precise equilibrium between SR Ca2+ reuptake and release. The review then discusses how disruption of this balance alters SR Ca2+ handling and may constitute a first step toward cardiac damage and malignant arrhythmias. In the last part of the review, this concept is exemplified in different cardiac diseases, like prediabetic and diabetic cardiomyopathy, digitalis intoxication and ischemia-reperfusion injury.
dc.languageeng
dc.publisherFrontiers Media
dc.relationinfo:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/article/10.3389/fphys.2019.01630/full
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3389/fphys.2019.01630
dc.rightshttps://creativecommons.org/licenses/by/2.5/ar/
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAPOPTOSIS
dc.subjectARRHYTHIMAS
dc.subjectDIABETIC MYOCARDIOPATHY
dc.subjectISQUEMIA-REPERFUSIÓN
dc.subjectPHOSPHOLAMBAN
dc.subjectRYANODINE RECEPTOR 2
dc.subjectSARCOPLASMIC RETICULUM CA2+-ATPASE
dc.titleUnbalance between sarcoplasmic reticulum Ca2 + uptake and release: A first step toward Ca2 + triggered arrhythmias and cardiac damage
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:ar-repo/semantics/artículo
dc.typeinfo:eu-repo/semantics/publishedVersion


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