dc.creatorSuarez, Sebastian
dc.creatorNeuman, Nicolás Ignacio
dc.creatorMarti, Marcelo Adrian
dc.creatorÁlvarez, Lucía
dc.creatorBikiel, Damian Ezequiel
dc.creatorBrondino, Carlos Dante
dc.creatorIvanovic Burmazovic, Ivana
dc.creatorMiljkovic, Jan Lj.
dc.creatorFilipovic, Milos R.
dc.creatorMarti, Marcelo Adrian
dc.creatorDoctorovich, Fabio
dc.date.accessioned2021-02-11T12:47:43Z
dc.date.accessioned2022-10-15T11:30:07Z
dc.date.available2021-02-11T12:47:43Z
dc.date.available2022-10-15T11:30:07Z
dc.date.created2021-02-11T12:47:43Z
dc.date.issued2015-03
dc.identifierSuarez, Sebastian; Neuman, Nicolás Ignacio; Marti, Marcelo Adrian; Álvarez, Lucía; Bikiel, Damian Ezequiel; et al.; Nitric oxide is reduced to HNO (azanone) by ascorbic acid, tyrosine, and other alcohols. A new route for azanone formation in biological media.; American Chemical Society; Journal of the American Chemical Society; 137; 14; 3-2015; 4720-4727
dc.identifier0002-7863
dc.identifierhttp://hdl.handle.net/11336/125436
dc.identifierCONICET Digital
dc.identifierCONICET
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/4381040
dc.description.abstractThe role of NO in biology is well established. However, an increasing body of evidence suggests that azanone (HNO), could also be involved in biological processes, some of which are attributed to NO. In this context, one of the most important and yet unanswered questions is whether and how HNO is produced in vivo. A possible route concerns the chemical or enzymatic reduction of NO. In the present work, we have taken advantage of a selective HNO sensing method, to show that NO is reduced to HNO by biologically relevant alcohols with moderate reducing capacity, such as ascorbate or tyrosine. The proposed mechanism involves a nucleophilic attack to NO by the alcohol, coupled to a proton transfer (PCNA: proton-coupled nucleophilic attack) and a subsequent decomposition of the so-produced radical to yield HNO and an alkoxyl radical. (Graph Presented).
dc.languageeng
dc.publisherAmerican Chemical Society
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1021/ja512343w
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectHNO
dc.subjectnitric oxide
dc.subjectnucleophilic attack
dc.subjectbiological media
dc.titleNitric oxide is reduced to HNO (azanone) by ascorbic acid, tyrosine, and other alcohols. A new route for azanone formation in biological media.
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:ar-repo/semantics/artículo
dc.typeinfo:eu-repo/semantics/publishedVersion


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