dc.creatorBonafina, Antonela
dc.creatorFontanet, Paula Aldana
dc.creatorParatcha, Gustavo
dc.creatorLedda, Maria Fernanda
dc.date.accessioned2019-11-25T21:17:18Z
dc.date.accessioned2022-10-15T11:19:54Z
dc.date.available2019-11-25T21:17:18Z
dc.date.available2022-10-15T11:19:54Z
dc.date.created2019-11-25T21:17:18Z
dc.date.issued2018-03
dc.identifierBonafina, Antonela; Fontanet, Paula Aldana; Paratcha, Gustavo; Ledda, Maria Fernanda; GDNF/GFRα1 Complex Abrogates Self-Renewing Activity of Cortical Neural Precursors Inducing Their Differentiation; Cell Press; Stem Cell Reports; 10; 3; 3-2018; 1000-1015
dc.identifier2213-6711
dc.identifierhttp://hdl.handle.net/11336/90065
dc.identifierCONICET Digital
dc.identifierCONICET
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/4380094
dc.description.abstractThe balance between factors leading to proliferation and differentiation of cortical neural precursors (CNPs) determines the correct cortical development. In this work, we show that GDNF and its receptor GFRα1 are expressed in the neocortex during the period of cortical neurogenesis. We show that the GDNF/GFRα1 complex inhibits the self-renewal capacity of mouse CNP cells induced by fibroblast growth factor 2 (FGF2), promoting neuronal differentiation. While GDNF leads to decreased proliferation of cultured cortical precursor cells, ablation of GFRα1 in glutamatergic cortical precursors enhances its proliferation. We show that GDNF treatment of CNPs promoted morphological differentiation even in the presence of the self-renewal-promoting factor, FGF2. Analysis of GFRα1-deficient mice shows an increase in the number of cycling cells during cortical development and a reduction in dendrite development of cortical GFRα1-expressing neurons. Together, these results indicate that GDNF/GFRα1 signaling plays an essential role in regulating the proliferative condition and the differentiation of cortical progenitors. In this article, Ledda and colleagues show that GDNF acting through its receptor GFRα1 plays a critical role in the maturation of cortical progenitors by counteracting FGF2 self-renewal activity on neural stem cells and promoting neuronal differentiation.
dc.languageeng
dc.publisherCell Press
dc.relationinfo:eu-repo/semantics/altIdentifier/url/http://linkinghub.elsevier.com/retrieve/pii/S2213671118300456
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1016/j.stemcr.2018.01.019
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCORTICAL PRECURSORS
dc.subjectGDNF
dc.subjectGFRΑ1
dc.subjectNEURONAL DIFFERENTIATION
dc.subjectPOSTMITOTIC NEURONS
dc.subjectPROLIFERATION
dc.titleGDNF/GFRα1 Complex Abrogates Self-Renewing Activity of Cortical Neural Precursors Inducing Their Differentiation
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:ar-repo/semantics/artículo
dc.typeinfo:eu-repo/semantics/publishedVersion


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