dc.creatorMarchionatti, Ana María
dc.creatorPerez, Adriana
dc.creatorRivoira, Maria Angelica
dc.creatorRodriguez, Valeria Andrea
dc.creatorTolosa, Nori Graciela
dc.date.accessioned2018-11-07T20:04:08Z
dc.date.accessioned2022-10-15T11:10:22Z
dc.date.available2018-11-07T20:04:08Z
dc.date.available2022-10-15T11:10:22Z
dc.date.created2018-11-07T20:04:08Z
dc.date.issued2017-04
dc.identifierMarchionatti, Ana María; Perez, Adriana; Rivoira, Maria Angelica; Rodriguez, Valeria Andrea; Tolosa, Nori Graciela; Lithocholic acid: A new emergent protector of intestinal calcium absorption under oxidant conditions; National Research Council Canada-NRC Research Press; Biochemistry and Cell Biology; 95; 2; 4-2017; 273-279
dc.identifier0829-8211
dc.identifierhttp://hdl.handle.net/11336/63932
dc.identifierCONICET Digital
dc.identifierCONICET
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/4379297
dc.description.abstractLCA and 1,25(OH)2D3 are vitamin D receptor ligands with different binding affinity. The secosteroid stimulates intestinal Ca2+ absorption. Whether LCA alters this process remains unknown. The aim of our work was to determine the effect of LCA on intestinal Ca2+ absorption in the absence or presence of NaDOC, bile acid that inhibits the cation transport. The data show that LCA by itself did not alter intestinal Ca2+ absorption, but prevented the inhibitory effect of NaDOC. The concomitant administration of LCA avoided the reduction of intestinal alkaline phosphatase activity caused by NaDOC. In addition, LCA blocked a decrease caused by NaDOC on gene and protein expression of molecules involved in the transcellular pathway of intestinal Ca2+ absorption. The oxidative stress and apoptosis triggered by NaDOC were abrogated by LCA co-treatment. In conclusion, LCA placed in the intestinal lumen protects intestinal Ca2+ absorption against the inhibitory effects caused by NaDOC. LCA avoids the reduction of the transcellular Ca2+ movement, apparently by blocking the oxidative stress and apoptosis triggered by NaDOC, normalizing the gene and protein expression of molecules involved in Ca2+ movement. Therefore, LCA might become a possible treatment to improve intestinal calcium absorption under oxidant conditions.
dc.languageeng
dc.publisherNational Research Council Canada-NRC Research Press
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1139/bcb-2016-0164
dc.relationinfo:eu-repo/semantics/altIdentifier/url/http://www.nrcresearchpress.com/doi/10.1139/bcb-2016-0164
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectApoptosis
dc.subjectIntestinal Ca2+ Absorption
dc.subjectLca
dc.subjectNadoc
dc.subjectOxidative Stress
dc.titleLithocholic acid: A new emergent protector of intestinal calcium absorption under oxidant conditions
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:ar-repo/semantics/artículo
dc.typeinfo:eu-repo/semantics/publishedVersion


Este ítem pertenece a la siguiente institución