dc.creator | Marchionatti, Ana María | |
dc.creator | Perez, Adriana | |
dc.creator | Rivoira, Maria Angelica | |
dc.creator | Rodriguez, Valeria Andrea | |
dc.creator | Tolosa, Nori Graciela | |
dc.date.accessioned | 2018-11-07T20:04:08Z | |
dc.date.accessioned | 2022-10-15T11:10:22Z | |
dc.date.available | 2018-11-07T20:04:08Z | |
dc.date.available | 2022-10-15T11:10:22Z | |
dc.date.created | 2018-11-07T20:04:08Z | |
dc.date.issued | 2017-04 | |
dc.identifier | Marchionatti, Ana María; Perez, Adriana; Rivoira, Maria Angelica; Rodriguez, Valeria Andrea; Tolosa, Nori Graciela; Lithocholic acid: A new emergent protector of intestinal calcium absorption under oxidant conditions; National Research Council Canada-NRC Research Press; Biochemistry and Cell Biology; 95; 2; 4-2017; 273-279 | |
dc.identifier | 0829-8211 | |
dc.identifier | http://hdl.handle.net/11336/63932 | |
dc.identifier | CONICET Digital | |
dc.identifier | CONICET | |
dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/4379297 | |
dc.description.abstract | LCA and 1,25(OH)2D3 are vitamin D receptor ligands with different binding affinity. The secosteroid stimulates intestinal Ca2+ absorption. Whether LCA alters this process remains unknown. The aim of our work was to determine the effect of LCA on intestinal Ca2+ absorption in the absence or presence of NaDOC, bile acid that inhibits the cation transport. The data show that LCA by itself did not alter intestinal Ca2+ absorption, but prevented the inhibitory effect of NaDOC. The concomitant administration of LCA avoided the reduction of intestinal alkaline phosphatase activity caused by NaDOC. In addition, LCA blocked a decrease caused by NaDOC on gene and protein expression of molecules involved in the transcellular pathway of intestinal Ca2+ absorption. The oxidative stress and apoptosis triggered by NaDOC were abrogated by LCA co-treatment. In conclusion, LCA placed in the intestinal lumen protects intestinal Ca2+ absorption against the inhibitory effects caused by NaDOC. LCA avoids the reduction of the transcellular Ca2+ movement, apparently by blocking the oxidative stress and apoptosis triggered by NaDOC, normalizing the gene and protein expression of molecules involved in Ca2+ movement. Therefore, LCA might become a possible treatment to improve intestinal calcium absorption under oxidant conditions. | |
dc.language | eng | |
dc.publisher | National Research Council Canada-NRC Research Press | |
dc.relation | info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1139/bcb-2016-0164 | |
dc.relation | info:eu-repo/semantics/altIdentifier/url/http://www.nrcresearchpress.com/doi/10.1139/bcb-2016-0164 | |
dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.subject | Apoptosis | |
dc.subject | Intestinal Ca2+ Absorption | |
dc.subject | Lca | |
dc.subject | Nadoc | |
dc.subject | Oxidative Stress | |
dc.title | Lithocholic acid: A new emergent protector of intestinal calcium absorption under oxidant conditions | |
dc.type | info:eu-repo/semantics/article | |
dc.type | info:ar-repo/semantics/artículo | |
dc.type | info:eu-repo/semantics/publishedVersion | |