Hearing loss genes reveal patterns of adaptive evolution at the coding and non-coding levels in mammals

dc.creatorTrigila, Anabella Paola
dc.creatorPisciottano, Francisco
dc.creatorFranchini, Lucia Florencia
dc.date.accessioned2022-01-14T17:20:21Z
dc.date.accessioned2022-10-15T11:04:00Z
dc.date.available2022-01-14T17:20:21Z
dc.date.available2022-10-15T11:04:00Z
dc.date.created2022-01-14T17:20:21Z
dc.date.issued2021-11
dc.identifierTrigila, Anabella Paola; Pisciottano, Francisco; Franchini, Lucia Florencia; Hearing loss genes reveal patterns of adaptive evolution at the coding and non-coding levels in mammals; BioMed Central; Bmc Biology; 19; 1; 11-2021; 1-24
dc.identifier1741-7007
dc.identifierhttp://hdl.handle.net/11336/150123
dc.identifierCONICET Digital
dc.identifierCONICET
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/4378725
dc.description.abstractMammals possess unique hearing capacities that differ significantly from those of the rest of the amniotes. In order to gain insights into the evolution of the mammalian inner ear, we aim to identify the set of genetic changes and the evolutionary forces that underlie this process. We hypothesize that genes that impair hearing when mutated in humans or in mice (hearing loss (HL) genes) must play important roles in the development and physiology of the inner ear and may have been targets of selective forces across the evolution of mammals. Additionally, we investigated if these HL genes underwent a human-specific evolutionary process that could underlie the evolution of phenotypic traits that characterize human hearing.
dc.languageeng
dc.publisherBioMed Central
dc.relationinfo:eu-repo/semantics/altIdentifier/url/https://bmcbiol.biomedcentral.com/articles/10.1186/s12915-021-01170-6
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1186/s12915-021-01170-6
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectINNER EAR,
dc.subjectEVOLUTION
dc.subjectHEARING LOSS
dc.subjectMAMMALS
dc.subjectTSARS
dc.subjectHARS
dc.titleHearing loss genes reveal patterns of adaptive evolution at the coding and non-coding levels in mammals
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:ar-repo/semantics/artículo
dc.typeinfo:eu-repo/semantics/publishedVersion


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