| dc.creator | Hoch, Nicolas Carlos | |
| dc.creator | Polo Ilacqua, Luis Mariano | |
| dc.date.accessioned | 2020-09-29T18:01:31Z | |
| dc.date.accessioned | 2022-10-15T10:56:11Z | |
| dc.date.available | 2020-09-29T18:01:31Z | |
| dc.date.available | 2022-10-15T10:56:11Z | |
| dc.date.created | 2020-09-29T18:01:31Z | |
| dc.date.issued | 2020-01 | |
| dc.identifier | Hoch, Nicolas Carlos; Polo Ilacqua, Luis Mariano; ADP-ribosylation: From molecular mechanisms to human disease; Sociedade Brasileira de Genética; Genetics and Molecular Biology; 43; 1; 1-2020; 1-14 | |
| dc.identifier | 1415-4757 | |
| dc.identifier | http://hdl.handle.net/11336/115088 | |
| dc.identifier | 1678-4685 | |
| dc.identifier | CONICET Digital | |
| dc.identifier | CONICET | |
| dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/4378070 | |
| dc.description.abstract | Post-translational modification of proteins by ADP-ribosylation, catalysed by poly (ADP-ribose) polymerases (PARPs) using NAD+ as a substrate, plays central roles in DNA damage signalling and repair, modulates a range of cellular signalling cascades and initiates programmed cell death by parthanatos. Here, we present mechanistic aspects of ADP-ribose modification, PARP activation and the cellular functions of ADP-ribose signalling, and discuss how this knowledge is uncovering therapeutic avenues for the treatment of increasingly prevalent human diseases such as cancer, ischaemic damage and neurodegeneration. | |
| dc.language | eng | |
| dc.publisher | Sociedade Brasileira de Genética | |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572020000200304&lng=en&nrm=iso | |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1590/1678-4685-gmb-2019-0075 | |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7198025/ | |
| dc.rights | https://creativecommons.org/licenses/by/2.5/ar/ | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.subject | ADP RIBOSE | |
| dc.subject | DNA DAMAGE RESPONSE | |
| dc.subject | DNA REPAIR | |
| dc.subject | PARP | |
| dc.subject | PARTHANATOS | |
| dc.title | ADP-ribosylation: From molecular mechanisms to human disease | |
| dc.type | info:eu-repo/semantics/article | |
| dc.type | info:ar-repo/semantics/artículo | |
| dc.type | info:eu-repo/semantics/publishedVersion | |
