dc.creator | Mazunder, Supata | |
dc.creator | Ghosal, Prodyut K. | |
dc.creator | Pujol, Carlos Alberto | |
dc.creator | Carlucci, Maria Josefina | |
dc.creator | Damonte, Elsa Beatriz | |
dc.creator | Ray, Bimalendu | |
dc.date.accessioned | 2020-03-30T16:02:45Z | |
dc.date.accessioned | 2022-10-15T10:43:40Z | |
dc.date.available | 2020-03-30T16:02:45Z | |
dc.date.available | 2022-10-15T10:43:40Z | |
dc.date.created | 2020-03-30T16:02:45Z | |
dc.date.issued | 2002-12 | |
dc.identifier | Mazunder, Supata; Ghosal, Prodyut K.; Pujol, Carlos Alberto; Carlucci, Maria Josefina; Damonte, Elsa Beatriz; et al.; Isolation, chemical investigation and antiviral activity of polysaccharides from Gracilaria corticata (Gracilariaceae, Rhodophyta); Elsevier Science; International Journal of Biological Macromolecules; 31; 12-2002; 87-95 | |
dc.identifier | 0141-8130 | |
dc.identifier | http://hdl.handle.net/11336/101330 | |
dc.identifier | CONICET Digital | |
dc.identifier | CONICET | |
dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/4376979 | |
dc.description.abstract | Polysaccharides were sequentially extracted from the agarophyte Gracilaria corticata. Chemical analysis combined with infrared spectroscopy showed that the cold water extracted material consists mainly of a high molecular weight sulfated galactan. Most of the sulfate groups are alkali labile and are located at C-4 of the 1,3-linked D-galactose units and C-6 of the 1,4-linked L-galactose residues. The autoclaved extracts contain agar type polysaccharide having a high pyruvate content and a variable degree of methylation, but were contaminated with floridean starch. 1 H-NMR studies indicate that methoxyl groups, when present, occur at C-6 of the 1,3-linked D-galactose units and C-2 of the 1,4-linked L-galactose residues of agar polymer. Bioassays showed that a high molecular weight galactan sulfate, exhibited selective antiviral activity against herpes simplex virus types 1 and 2, likely due to an inhibition of the initial virus attachment to the host cell. | |
dc.language | eng | |
dc.publisher | Elsevier Science | |
dc.relation | info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0141813002000703 | |
dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/S0141-8130(02)00070-3 | |
dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | |
dc.rights | info:eu-repo/semantics/restrictedAccess | |
dc.subject | Gracilaria corticata | |
dc.subject | Galactan sulfate | |
dc.subject | Agar | |
dc.subject | Anticoagulant activity | |
dc.subject | Anti-herpes simplex virus activity | |
dc.subject | Starch | |
dc.title | Isolation, chemical investigation and antiviral activity of polysaccharides from Gracilaria corticata (Gracilariaceae, Rhodophyta) | |
dc.type | info:eu-repo/semantics/article | |
dc.type | info:ar-repo/semantics/artículo | |
dc.type | info:eu-repo/semantics/publishedVersion | |