Ceramide-1-phosphate has protective properties against cyclophosphamide-induced ovarian damage in a mice model of premature ovarian failure

dc.creatorPascuali, Natalia Marisa
dc.creatorScotti, Leopoldina
dc.creatorDi Pietro, Mariana
dc.creatorOubiña, Gonzalo
dc.creatorBas, Diana Ester
dc.creatorMay, Maria
dc.creatorGómez Muñoz, Antonio
dc.creatorCuasnicu, Patricia Sara
dc.creatorCohen, Debora Juana
dc.creatorTesone, Marta
dc.creatorAbramovich, Dalhia Nurit
dc.creatorParborell, Maria Fernanda Agustina
dc.date.accessioned2019-10-08T19:34:42Z
dc.date.accessioned2022-10-15T10:40:55Z
dc.date.available2019-10-08T19:34:42Z
dc.date.available2022-10-15T10:40:55Z
dc.date.created2019-10-08T19:34:42Z
dc.date.issued2018-05
dc.identifierPascuali, Natalia Marisa; Scotti, Leopoldina; Di Pietro, Mariana; Oubiña, Gonzalo; Bas, Diana Ester; et al.; Ceramide-1-phosphate has protective properties against cyclophosphamide-induced ovarian damage in a mice model of premature ovarian failure; Oxford University Press; Human Reproduction; 33; 5; 5-2018; 844-859
dc.identifier0268-1161
dc.identifierhttp://hdl.handle.net/11336/85366
dc.identifierCONICET Digital
dc.identifierCONICET
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/4376714
dc.description.abstractIs ceramide-1-phosphate (C1P) an ovarian protective agent during alkylating chemotherapy?Local administration of C1P drastically reduces ovarian damage induced by cyclophosphamide (Cy) via protection of follicular reserve, restoration of hormone levels, inhibition of apoptosis and improvement of stromal vasculature, while protecting fertility, oocyte quality and uterine morphology.
dc.languageeng
dc.publisherOxford University Press
dc.relationinfo:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/humrep/article/33/5/844/4925330
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1093/humrep/dey045
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectCHEMOTHERAPY
dc.subjectGONADOTOXICITY
dc.subjectONCOFERTILITY
dc.subjectOVARIAN RESERVE
dc.subjectSPHINGOLIPIDS
dc.titleCeramide-1-phosphate has protective properties against cyclophosphamide-induced ovarian damage in a mice model of premature ovarian failure
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:ar-repo/semantics/artículo
dc.typeinfo:eu-repo/semantics/publishedVersion


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