dc.creatorLazar, Tamas
dc.creatorMartinez Perez, Elizabeth
dc.creatorQuaglia, Federica
dc.creatorHatos, András
dc.creatorChemes, Lucia Beatriz
dc.creatorIserte, Javier Alonso
dc.creatorMéndez, Nicolás Agustín
dc.creatorGarrone, Nicolás Agustín
dc.creatorSaldaño, Tadeo Enrique
dc.creatorMarchetti, Julia
dc.creatorVelez Rueda, Ana Julia
dc.creatorBernadó, Pau
dc.creatorBlackledge, Martin
dc.creatorCordeiro, Tiago N.
dc.creatorFagerberg, Eric
dc.creatorForman Kay, Julie D
dc.creatorFornasari, Maria Silvina
dc.creatorGibson, Toby James
dc.creatorGomes, Gregory Neal W
dc.creatorGradinaru, Claudiu C.
dc.creatorHead Gordon, Teresa
dc.creatorJensen, Malene Ringkjøbing
dc.creatorLemke, Edward A
dc.creatorLonghi, Sonia
dc.creatorMarino Buslje, Cristina
dc.creatorMinervini, Giovanni
dc.creatorMittag, Tanja
dc.creatorMonzon, Alexander Miguel
dc.creatorPappu, Rohit V.
dc.creatorParisi, Gustavo Daniel
dc.date.accessioned2022-08-10T13:44:28Z
dc.date.accessioned2022-10-15T10:34:49Z
dc.date.available2022-08-10T13:44:28Z
dc.date.available2022-10-15T10:34:49Z
dc.date.created2022-08-10T13:44:28Z
dc.date.issued2021-01-08
dc.identifierLazar, Tamas; Martinez Perez, Elizabeth; Quaglia, Federica; Hatos, András; Chemes, Lucia Beatriz; et al.; PED in 2021: A major update of the protein ensemble database for intrinsically disordered proteins; Oxford University Press; Nucleic Acids Research; 49; D1; 8-1-2021; D404-D411
dc.identifier1362-4962
dc.identifierhttp://hdl.handle.net/11336/164928
dc.identifier0305-1048
dc.identifierCONICET Digital
dc.identifierCONICET
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/4376182
dc.description.abstractThe Protein Ensemble Database (PED) (https://proteinensemble.org), which holds structural ensembles of intrinsically disordered proteins (IDPs), has been significantly updated and upgraded since its last release in 2016. The new version, PED 4.0, has been completely redesigned and reimplemented with cutting-edge technology and now holds about six times more data (162 versus 24 entries and 242 versus 60 structural ensembles) and a broader representation of state of the art ensemble generation methods than the previous version. The database has a completely renewed graphical interface with an interactive feature viewer for region-based annotations, and provides a series of descriptors of the qualitative and quantitative properties of the ensembles. High quality of the data is guaranteed by a new submission process, which combines both automatic and manual evaluation steps. A team of biocurators integrate structured metadata describing the ensemble generation methodology, experimental constraints and conditions. A new search engine allows the user to build advanced queries and search all entry fields including cross-references to IDP-related resources such as DisProt, MobiDB, BMRB and SASBDB. We expect that the renewed PED will be useful for researchers interested in the atomic-level understanding of IDP function, and promote the rational, structure-based design of IDP-targeting drugs.
dc.languageeng
dc.publisherOxford University Press
dc.relationinfo:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/nar/article/49/D1/D404/6030232
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1093/nar/gkaa1021
dc.rightshttps://creativecommons.org/licenses/by-nc/2.5/ar/
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectENSEMBLE
dc.subjectDISORDER
dc.subjectPROTEINS
dc.subjectIDP
dc.titlePED in 2021: A major update of the protein ensemble database for intrinsically disordered proteins
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:ar-repo/semantics/artículo
dc.typeinfo:eu-repo/semantics/publishedVersion


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