dc.creatorBarbosa, María Carolina
dc.creatorGrosso, Rubén Adrián
dc.creatorFader Kaiser, Claudio Marcelo
dc.date.accessioned2020-12-17T15:15:09Z
dc.date.accessioned2022-10-15T09:57:06Z
dc.date.available2020-12-17T15:15:09Z
dc.date.available2022-10-15T09:57:06Z
dc.date.created2020-12-17T15:15:09Z
dc.date.issued2019-01
dc.identifierBarbosa, María Carolina; Grosso, Rubén Adrián; Fader Kaiser, Claudio Marcelo; Hallmarks of aging: An autophagic perspective; Frontiers Media S.A.; Frontiers in Endocrinology; 9; 790; 1-2019; 1-13
dc.identifier1664-2392
dc.identifierhttp://hdl.handle.net/11336/120768
dc.identifierCONICET Digital
dc.identifierCONICET
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/4372980
dc.description.abstractAutophagy is a major protein turnover pathway by which cellular components are delivered into the lysosomes for degradation and recycling. This intracellular process is able to maintain cellular homeostasis under stress conditions, and its dysregulation could lead to the development of physiological alterations. The autophagic activity has been found to decrease with age, likely contributing to the accumulation of damaged macromolecules and organelles during aging. Interestingly, failure of the autophagic process has been reported to worsen aging-associated diseases, such as neurodegeneration or cancer, among others. Likewise, it has been proposed in different organisms that maintenance of a proper autophagic activity contributes to extending longevity. In this review, we discuss recent papers showing the impact of autophagy on cell activity and age-associated diseases, highlighting the relevance of this process to the hallmarks of aging. Thus, understanding how autophagy plays an important role in aging opens new avenues for the discovery of biochemical and pharmacological targets and the development of novel anti-aging therapeutic approaches.
dc.languageeng
dc.publisherFrontiers Media S.A.
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3389/fendo.2018.00790
dc.relationinfo:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fendo.2018.00790/full
dc.rightshttps://creativecommons.org/licenses/by/2.5/ar/
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAGING
dc.subjectAUTOPHAGY
dc.subjectHALLMARKS OF AGING
dc.subjectMITOPHAGY
dc.subjectROS
dc.titleHallmarks of aging: An autophagic perspective
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:ar-repo/semantics/artículo
dc.typeinfo:eu-repo/semantics/publishedVersion


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