Structure-activity relationship study of homoallylamines and related derivatives acting as antifungal agents

dc.creatorSuvire, Fernando Daniel
dc.creatorSortino, Maximiliano Andrés
dc.creatorKouznetsov, Vladimir V.
dc.creatorVargas M, Leonor Y.
dc.creatorZacchino, Susana Alicia Stella
dc.creatorCruz, Uriel Mora
dc.creatorEnriz, Ricardo Daniel
dc.date.accessioned2021-08-23T15:34:13Z
dc.date.accessioned2022-10-15T09:51:52Z
dc.date.available2021-08-23T15:34:13Z
dc.date.available2022-10-15T09:51:52Z
dc.date.created2021-08-23T15:34:13Z
dc.date.issued2006-03-15
dc.identifierSuvire, Fernando Daniel; Sortino, Maximiliano Andrés; Kouznetsov, Vladimir V.; Vargas M, Leonor Y.; Zacchino, Susana Alicia Stella; et al.; Structure-activity relationship study of homoallylamines and related derivatives acting as antifungal agents; Elsevier; Bioorganic & Medicinal Chemistry; 14; 6; 15-3-2006; 1851-1862
dc.identifier0968-0896
dc.identifierhttp://hdl.handle.net/11336/138702
dc.identifierCONICET Digital
dc.identifierCONICET
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/4372530
dc.description.abstractThe synthesis, in vitro evaluation, and structure-activity relationship studies of homoallylamines and related derivatives acting as antifungal agents are reported. Among them, compounds N-(4-bromophenyl)-N-(2-furylmethyl)amine and N-(4-chlorophenyl)-N-(2-furylmethyl)amine reported here exhibited remarkable antifungal activity against dermatophytes. Theoretical calculations allow us to determine the minimal structural requirements to produce the antifungal response and can provide a guide for the design of compounds with these properties.
dc.languageeng
dc.publisherElsevier
dc.relationinfo:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0968089605010230
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.bmc.2005.10.036
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectANTIFUNGAL ACTIVITY
dc.subjectHOMOALLYLAMINES
dc.subjectSAR
dc.subjectSYNTHESIS
dc.titleStructure-activity relationship study of homoallylamines and related derivatives acting as antifungal agents
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:ar-repo/semantics/artículo
dc.typeinfo:eu-repo/semantics/publishedVersion


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