Science based calibration for the extraction of 'analyte-specific' HPLC-DAD chromatograms in environmental analysis

dc.creatorKuligowski, J.
dc.creatorMartínez Galera, M.
dc.creatorGil García, M. D.
dc.creatorCulzoni, Maria Julia
dc.creatorGoicoechea, Hector Casimiro
dc.creatorGarrigues, S.
dc.creatorQuintás, G.
dc.creatorde la Guardia, Miguel
dc.date.accessioned2019-04-16T14:57:16Z
dc.date.accessioned2022-10-15T09:43:35Z
dc.date.available2019-04-16T14:57:16Z
dc.date.available2022-10-15T09:43:35Z
dc.date.created2019-04-16T14:57:16Z
dc.date.issued2011-01
dc.identifierKuligowski, J.; Martínez Galera, M.; Gil García, M. D.; Culzoni, Maria Julia; Goicoechea, Hector Casimiro; et al.; Science based calibration for the extraction of 'analyte-specific' HPLC-DAD chromatograms in environmental analysis; Elsevier Science; Talanta; 83; 4; 1-2011; 1158-1165
dc.identifier0039-9140
dc.identifierhttp://hdl.handle.net/11336/74459
dc.identifierCONICET Digital
dc.identifierCONICET
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/4371803
dc.description.abstractMultivariate science based calibration (SBC) has been applied to the resolution of overlapped peaks in liquid chromatography with diode array detection (LC-DAD). Complex river water samples spiked with 11 pharmaceutical substances resulted in poorly resolved chromatograms containing additional peaks from interfering matrix compounds and a change in the background absorbance due to the mobile phase gradient. Applying the present multivariate approach it was possible to resolve all 11 analytes from overlapping peaks, obtaining linear calibration lines (R2 > 0.96). Recovery percentages on spiked samples ranged between 74.6 and 113.5%, which are quite satisfactory taking into account the low concentration ranges considered to 1-7 μg L-1.
dc.languageeng
dc.publisherElsevier Science
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/http://doi.org/10.1016/j.talanta.2010.07.060
dc.relationinfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0039914010005904
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectENVIRONMENTAL ANALYSIS
dc.subjectHIGH PERFORMANCE LIQUID CHROMATOGRAPHY-DIODE ARRAY DETECTION (HPLC-DAD)
dc.subjectSCIENCE BASED CALIBRATION
dc.titleScience based calibration for the extraction of 'analyte-specific' HPLC-DAD chromatograms in environmental analysis
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:ar-repo/semantics/artículo
dc.typeinfo:eu-repo/semantics/publishedVersion


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