Application of a chemometric method for simultaneous determination of acetaminophen and diclofenac in content-uniformity and drug-dissolution studies

dc.creatorVignaduzzo, Silvana Edit
dc.creatorMaggio, Ruben Mariano
dc.creatorCastellano, Patricia Margarita
dc.creatorKaufman, Teodoro Saul
dc.date.accessioned2021-07-21T12:09:05Z
dc.date.accessioned2022-10-15T09:18:29Z
dc.date.available2021-07-21T12:09:05Z
dc.date.available2022-10-15T09:18:29Z
dc.date.created2021-07-21T12:09:05Z
dc.date.issued2005-07
dc.identifierVignaduzzo, Silvana Edit; Maggio, Ruben Mariano; Castellano, Patricia Margarita; Kaufman, Teodoro Saul; Application of a chemometric method for simultaneous determination of acetaminophen and diclofenac in content-uniformity and drug-dissolution studies; Springer Heidelberg; Analytical and Bioanalytical Chemistry; 382; 7; 7-2005; 1711-1714
dc.identifier1618-2642
dc.identifierhttp://hdl.handle.net/11336/136549
dc.identifierCONICET Digital
dc.identifierCONICET
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/4369549
dc.description.abstractA new, repeatable, and rapid method has been developed for resolution of binary mixtures of acetaminophen and diclofenac with minimum sample pretreatment and without separation of the analytes. The method, based on the PLS1 processing of absorbance data in the UV region, was successfully used for quantification of the drug content of three tablet preparations. The results obtained were in good agreement with HPLC recovery data. The method also enabled determination of drug-dissolution profiles of these commercial tablets, by simultaneous determination of both analytes during the dissolution test.
dc.languageeng
dc.publisherSpringer Heidelberg
dc.relationinfo:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007/s00216-005-3314-1
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1007/s00216-005-3314-1
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectACETAMINOPHEN
dc.subjectCHEMOMETRIC METHOD
dc.subjectDICLOFENAC
dc.subjectDISSOLUTION
dc.subjectPLS
dc.titleApplication of a chemometric method for simultaneous determination of acetaminophen and diclofenac in content-uniformity and drug-dissolution studies
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:ar-repo/semantics/artículo
dc.typeinfo:eu-repo/semantics/publishedVersion


Este ítem pertenece a la siguiente institución