Unsaturated fatty acids and alloxan diabetes

Abstract

I has been shown dietary factors can influence the toxic and diabetogenic action of alloxan. György and Rose (´48) observed high toxicity of alloxan when the experimental animals were fed diets free from yeast and high in lard or coconut oil, and obtained some reduction in the early mortality by supplementing the diets with tocopherol or yeast. Compared with rats fed a high carbohydate diet, previous subsistence on a high lard ration has been found to increase the sensivity of the animals to the toxic diabetogenic action of alloxan (Martinez '45, Houssay and Martinez, '47, Houssay and Martinez, '48).