dc.creatorPampillo, Macarena
dc.creatorScimonelli, Teresa
dc.creatorBottino, Maria Cecilia
dc.creatorDuvilanski, Beatriz Haydee
dc.creatorRettori, Valeria
dc.creatorSeilicovich, Adriana
dc.creatorLasaga, Mercedes Isabel
dc.date.accessioned2021-07-26T13:24:13Z
dc.date.accessioned2022-10-15T09:13:46Z
dc.date.available2021-07-26T13:24:13Z
dc.date.available2022-10-15T09:13:46Z
dc.date.created2021-07-26T13:24:13Z
dc.date.issued2002-12
dc.identifierPampillo, Macarena; Scimonelli, Teresa; Bottino, Maria Cecilia; Duvilanski, Beatriz Haydee; Rettori, Valeria; et al.; The effect of D-aspartate on luteinizing hormone-releasing hormone, α-melanocyte-stimulating hormone, GABA and dopamine release; Lippincott Williams; Neuroreport; 13; 12-2002; 2341-2344
dc.identifier0959-4965
dc.identifierhttp://hdl.handle.net/11336/136904
dc.identifierCONICET Digital
dc.identifierCONICET
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/4369109
dc.description.abstractSince D-aspartate stimulates prolactin and LH release, our objective was to determine whether D-aspartate modifies the release of hypothalamic and posterior pituitary factors involved in the control of their secretion and whether its effects on these tissues are exerted through NMDA receptors and mediated by nitric oxide. In the hypothalamus, D-aspartate stimulated luteinizing hormone-releasing hormone (LHRH), alpha-melanocyte-stimulating hormone (alpha-MSH) and GABA release and inhibited dopamine release through interaction with NMDA receptors. It increased nitric oxide synthase (NOS) activity, and its effects on LHRH and hypothalamic GABA release were blunted when NOS was inhibited. In the posterior pituitary gland, D-aspartate inhibited GABA release but had no effect on dopamine or alpha-MSH release. We report that D-aspartate differentially affects the release of hypothalamic and posterior pituitary factors involved in the regulation of pituitary hormone secretion.
dc.languageeng
dc.publisherLippincott Williams
dc.relationinfo:eu-repo/semantics/altIdentifier/url/https://journals.lww.com/neuroreport/Abstract/2002/12030/The_effect_of_D_aspartate_on_luteinizing.34.aspx
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectD-aspartate
dc.subjectLHRH
dc.subjectalpha-MSH
dc.subjectGABA
dc.titleThe effect of D-aspartate on luteinizing hormone-releasing hormone, α-melanocyte-stimulating hormone, GABA and dopamine release
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:ar-repo/semantics/artículo
dc.typeinfo:eu-repo/semantics/publishedVersion


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