dc.creatorDella Vedova, Maria Cecilia
dc.creatorSoler Garcia, Florencia Martina
dc.creatorMuñoz, Marcos David
dc.creatorFornes, Miguel Walter
dc.creatorGomez-Mejiba, Sandra Esther
dc.creatorGomez, Nidia Noemí
dc.creatorRamirez, Dario
dc.date.accessioned2020-11-21T22:52:42Z
dc.date.accessioned2022-10-15T08:58:25Z
dc.date.available2020-11-21T22:52:42Z
dc.date.available2022-10-15T08:58:25Z
dc.date.created2020-11-21T22:52:42Z
dc.date.issued2019-07-30
dc.identifierDella Vedova, Maria Cecilia; Soler Garcia, Florencia Martina; Muñoz, Marcos David; Fornes, Miguel Walter; Gomez-Mejiba, Sandra Esther; et al.; Diet-Induced Pulmonary Inflammation and Incipient Fibrosis in Mice: a Possible Role of Neutrophilic Inflammation; Springer/Plenum Publishers; Inflammation; 42; 5; 30-7-2019; 1886-1900
dc.identifier0360-3997
dc.identifierhttp://hdl.handle.net/11336/118732
dc.identifier1573-2576
dc.identifierCONICET Digital
dc.identifierCONICET
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/4367756
dc.description.abstractChicken fat and fructose are added into food-processing to reduce costs and enhance acceptability; however, these additives turn food into unhealthy and hypercaloric meals. Herein we have hypothesized that chronic feeding with chicken fat and fructose, together or by separate, can cause pulmonary redox and inflammatory changes. These changes are particularly related to neutrophils and myeloperoxidase, with consequent changes in the organ histophysiology. To test this hypothesis, we fed mice for 16 weeks with either control food (low-fat diet, LFD) or control food supplemented with 22% chicken fat and with or without 10% fructose in the drinking water. At the end of the feeding regimen, we measured redox and inflammatory changes in the lung with particular emphasis on neutrophil accumulation/activation and molecular-histological markers of fibrosis. Our results suggest that a diet supplemented with chicken fat and fructose causes additive effects on pulmonary oxidative stress, inflammation, and a pro-fibrotic status. Neutrophilic inflammation may play a critical role in pulmonary pathology associated with metabolic syndrome.
dc.languageeng
dc.publisherSpringer/Plenum Publishers
dc.relationinfo:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007%2Fs10753-019-01051-9
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1007/s10753-019-01051-9
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectDIET
dc.subjectMETABOLIC SYNDROME
dc.subjectNeutrophilic inflammation
dc.subjectMyeloperoxidase
dc.subjectIncipient lung fibrosis
dc.titleDiet-Induced Pulmonary Inflammation and Incipient Fibrosis in Mice: a Possible Role of Neutrophilic Inflammation
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:ar-repo/semantics/artículo
dc.typeinfo:eu-repo/semantics/publishedVersion


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