dc.creator | Azevedo, Andreia Aparecida | |
dc.creator | Figueiredo, Ricardo Rodrigues | |
dc.creator | Elgoyhen, Ana Belen | |
dc.creator | Langguth, Berthold | |
dc.creator | Penido, Norma De Oliveira | |
dc.creator | Schlee, Winfried | |
dc.date.accessioned | 2018-11-28T20:20:29Z | |
dc.date.accessioned | 2022-10-15T08:57:46Z | |
dc.date.available | 2018-11-28T20:20:29Z | |
dc.date.available | 2022-10-15T08:57:46Z | |
dc.date.created | 2018-11-28T20:20:29Z | |
dc.date.issued | 2017-09-21 | |
dc.identifier | Azevedo, Andreia Aparecida; Figueiredo, Ricardo Rodrigues; Elgoyhen, Ana Belen; Langguth, Berthold; Penido, Norma De Oliveira; et al.; Tinnitus treatment with oxytocin: A pilot study; Frontiers Research Foundation; Frontiers in Neurology; 8; SEP; 21-9-2017; 1-7; 494 | |
dc.identifier | http://hdl.handle.net/11336/65534 | |
dc.identifier | 1664-2295 | |
dc.identifier | CONICET Digital | |
dc.identifier | CONICET | |
dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/4367715 | |
dc.description.abstract | Introduction: Tinnitus is the perception of sound in the absence of an external stimulus. It is a frequent condition for which there is as yet no pharmacological treatment approved. Auditory and non-auditory pathways are involved in tinnitus' pathophysiology. Oxytocin is a neurohormone and eventual neurotransmitter that plays a complex role in social cognition and behavior. Objective: To evaluate the potential of oxytocin as a tinnitus treatment. Study design: Two studies were performed. Study 1 was a long-term open pilot study, while study 2 investigated short-term effects with a double-blinded placebo-controlled cross-over study. Setting: Ambulatory ENT care. Subjects and method: In study 1, 15 patients were investigated over a 10-week period in an open pilot study. In study 2, 16 patients were included in a placebo-controlled crossover trial to investigate short-term effects following a single dose. Results: For the long-term study (study 1), analysis of variance revealed a significant decrease in tinnitus sensation, both for the Tinnitus Handicap Inventory and Clinical Global Impression (CGI). Also, the short-term effects in study 2 revealed a significant reduction of tinnitus because of the oxytocin nasal spray as measured with the Visual Analog Scale and the CGI Scale. Conclusion: These preliminary studies demonstrated that oxytocin may represent a helpful tool for treating tinnitus and further larger controlled studies are warranted. | |
dc.language | eng | |
dc.publisher | Frontiers Research Foundation | |
dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3389/fneur.2017.00494 | |
dc.relation | info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fneur.2017.00494/full | |
dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.subject | HEARING DISORDERS | |
dc.subject | NASAL SPRAYS | |
dc.subject | OXYTOCIN | |
dc.subject | PHARMACOTHERAPY | |
dc.subject | TINNITUS | |
dc.title | Tinnitus treatment with oxytocin: A pilot study | |
dc.type | info:eu-repo/semantics/article | |
dc.type | info:ar-repo/semantics/artículo | |
dc.type | info:eu-repo/semantics/publishedVersion | |