Chemometrics-assisted simple UV-spectroscopic determination of carbamazepine in human serum and comparison with reference methods

dc.creatorCámara, María Silvia
dc.creatorMastandrea, Carlos Raúl
dc.creatorGoicoechea, Hector Casimiro
dc.date.accessioned2020-04-15T19:20:47Z
dc.date.accessioned2022-10-15T08:51:12Z
dc.date.available2020-04-15T19:20:47Z
dc.date.available2022-10-15T08:51:12Z
dc.date.created2020-04-15T19:20:47Z
dc.date.issued2005-09
dc.identifierCámara, María Silvia; Mastandrea, Carlos Raúl; Goicoechea, Hector Casimiro; Chemometrics-assisted simple UV-spectroscopic determination of carbamazepine in human serum and comparison with reference methods; Elsevier Science; Journal Of Biochemical And Biophysical Methods; 64; 9-2005; 153-166
dc.identifier0165-022X
dc.identifierhttp://hdl.handle.net/11336/102674
dc.identifierCONICET Digital
dc.identifierCONICET
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/4367133
dc.description.abstractIn the present report, CBZ is determined on real patients samples by using a procedure completely assisted by chemometric tools. Firstly, a response surface methodology based on a mixture design was applied in order to select the best conditions in the extraction step. Finally, multivariate calibration PLS-1 was applied to second derivative UV spectra eliminating a shift baseline effect originated in the extraction procedure. The performance assessment included: a) a three level precision study, b) a recovery study analysing spiked samples, and c) method comparison with HPLC and FPIA methods applied on real patient samples. The results obtained show the potentiality of the presently studied methodology for the following of patients treated with this anticonvulsivant.
dc.languageeng
dc.publisherElsevier Science
dc.relationinfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0165022X05001119
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1016/j.jbbm.2005.07.001
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectCARBAMAZEPINE
dc.subjectSERUM SAMPLES
dc.subjectCHEMOMETRICS
dc.subjectPARTIAL LEAST SQUARES REGRESSION
dc.titleChemometrics-assisted simple UV-spectroscopic determination of carbamazepine in human serum and comparison with reference methods
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:ar-repo/semantics/artículo
dc.typeinfo:eu-repo/semantics/publishedVersion


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