dc.creator | Parra, Federico Leonel | |
dc.creator | Frank, Fernanda María | |
dc.creator | Alliani, Bruno Fernando | |
dc.creator | Romero, Eder Lilia | |
dc.creator | Petray, Patricia Beatriz | |
dc.date.accessioned | 2021-12-22T17:11:54Z | |
dc.date.accessioned | 2022-10-15T08:23:54Z | |
dc.date.available | 2021-12-22T17:11:54Z | |
dc.date.available | 2022-10-15T08:23:54Z | |
dc.date.created | 2021-12-22T17:11:54Z | |
dc.date.issued | 2020-05 | |
dc.identifier | Parra, Federico Leonel; Frank, Fernanda María; Alliani, Bruno Fernando; Romero, Eder Lilia; Petray, Patricia Beatriz; Imiquimod-loaded nanoarchaeosomes as a promising immunotherapy against Trypanosoma cruzi infection; Elsevier Science; Colloids and Surfaces B: Biointerfaces; 189; 5-2020; 1-9 | |
dc.identifier | 0927-7765 | |
dc.identifier | http://hdl.handle.net/11336/149202 | |
dc.identifier | CONICET Digital | |
dc.identifier | CONICET | |
dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/4364722 | |
dc.description.abstract | The purpose of this study was to evaluate the efficacy of imiquimod-containing nanovesicles prepared with lipids extracted from the hyperhalophile archaebacterium Halorubrum tebenquichense (nanoARC-IMQ) to induce protection against Trypanosoma cruzi infection. The therapeutic efficacy of archaeolipid nanovesicles was assessed in an experimental murine model of acute infection with T. cruzi. The administration of nanoARQ-IMQ prevented mortality as compared to infected untreated animals, reduced parasitemia levels and diminished myocardial and musculoskeletal lesions in mice infected with a lethal strain of T. cruzi. Our findings suggest that the immunotherapy with nanoARC-IMQ has potential to limit the progression of Chagas disease. | |
dc.language | eng | |
dc.publisher | Elsevier Science | |
dc.relation | info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0927776520300801 | |
dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.colsurfb.2020.110850 | |
dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | |
dc.rights | info:eu-repo/semantics/restrictedAccess | |
dc.subject | ARCHAEBACTERIA | |
dc.subject | IMIQUIMOD | |
dc.subject | IMMUNOTHERAPY | |
dc.subject | NANOVESICLES | |
dc.subject | TRYPANOSOMA CRUZI INFECTION | |
dc.title | Imiquimod-loaded nanoarchaeosomes as a promising immunotherapy against Trypanosoma cruzi infection | |
dc.type | info:eu-repo/semantics/article | |
dc.type | info:ar-repo/semantics/artículo | |
dc.type | info:eu-repo/semantics/publishedVersion | |