Increase in IS256 transposition in invasive vancomycin heteroresistant Staphylococcus aureus isolate belonging to ST100 and its derived VISA mutants

dc.creatorDi Gregorio, Sabrina Noelia
dc.creatorFernandez, Silvina
dc.creatorPerazzi, Beatriz Elizabeth
dc.creatorBello, Natalia
dc.creatorFamiglietti, Angela María Rosa
dc.creatorMollerach, Marta Eugenia
dc.date.accessioned2020-10-01T21:00:34Z
dc.date.accessioned2022-10-15T08:12:26Z
dc.date.available2020-10-01T21:00:34Z
dc.date.available2022-10-15T08:12:26Z
dc.date.created2020-10-01T21:00:34Z
dc.date.issued2016-05
dc.identifierDi Gregorio, Sabrina Noelia; Fernandez, Silvina; Perazzi, Beatriz Elizabeth; Bello, Natalia; Famiglietti, Angela María Rosa; et al.; Increase in IS256 transposition in invasive vancomycin heteroresistant Staphylococcus aureus isolate belonging to ST100 and its derived VISA mutants; Elsevier Science; Infection, Genetics and Evolution; 43; 5-2016; 197-202
dc.identifier1567-1348
dc.identifierhttp://hdl.handle.net/11336/115322
dc.identifierCONICET Digital
dc.identifierCONICET
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/4363801
dc.description.abstractIn Staphylococcus aureus, transposition of IS256 has been described to play an important role in biofilm formation and antibiotic resistance. This study describes the molecular characterization of two clinical heterogeneous vancomycin-intermediate S. aureus (hVISA) isolates recovered from the same patient (before and after antibiotic treatment) and two VISA derivatives obtained by serial passages in the presence of vancomycin. Our results showed that antibiotic treatment (in vivo and in vitro) could enhance IS256 transposition, being responsible for the eventual loss of agr function. As far as we know this is the first study that reports the increase of IS256 transposition in isogenic strains after antibiotic treatment in a clinical setting.
dc.languageeng
dc.publisherElsevier Science
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.meegid.2016.05.001
dc.relationinfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S1567134816301691
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectVANCOMYCIN HETERORESISTNAT
dc.subjectSTAPHYLOCOCCUS AUREUS
dc.subjectVISA MUTANTS
dc.subjectHVISA/VISA
dc.subjectIS256 TRANSPOSITION
dc.subjectS. AUREUS
dc.titleIncrease in IS256 transposition in invasive vancomycin heteroresistant Staphylococcus aureus isolate belonging to ST100 and its derived VISA mutants
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:ar-repo/semantics/artículo
dc.typeinfo:eu-repo/semantics/publishedVersion


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