Chromatin, DNA structure and alternative splicing

dc.creatorNieto Moreno, Nicolás
dc.creatorGiono, Luciana Eugenia
dc.creatorCambindo Botto, Adrian Edgardo
dc.creatorMuñoz, Manuel Javier
dc.creatorKornblihtt, Alberto Rodolfo
dc.date.accessioned2019-10-01T18:10:38Z
dc.date.accessioned2022-10-15T06:24:16Z
dc.date.available2019-10-01T18:10:38Z
dc.date.available2022-10-15T06:24:16Z
dc.date.created2019-10-01T18:10:38Z
dc.date.issued2015-06
dc.identifierNieto Moreno, Nicolás; Giono, Luciana Eugenia; Cambindo Botto, Adrian Edgardo; Muñoz, Manuel Javier; Kornblihtt, Alberto Rodolfo; Chromatin, DNA structure and alternative splicing; Elsevier Science; FEBS Letters; 589; 22; 6-2015; 3370-3378
dc.identifier0014-5793
dc.identifierhttp://hdl.handle.net/11336/84947
dc.identifierCONICET Digital
dc.identifierCONICET
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/4354931
dc.description.abstractCoupling of transcription and alternative splicing via regulation of the transcriptional elongation rate is a well-studied phenomenon. Template features that act as roadblocks for the progression of RNA polymerase II comprise histone modifications and variants, DNA-interacting proteins and chromatin compaction. These may affect alternative splicing decisions by inducing pauses or decreasing elongation rate that change the time-window for splicing regulatory sequences to be recognized. Herein we discuss the evidence supporting the influence of template structural modifications on transcription and splicing, and provide insights about possible roles of non-B DNA conformations on the regulation of alternative splicing.
dc.languageeng
dc.publisherElsevier Science
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.febslet.2015.08.002
dc.relationinfo:eu-repo/semantics/altIdentifier/url/https://febs.onlinelibrary.wiley.com/doi/full/10.1016/j.febslet.2015.08.002
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectALTERNATIVE SPLICING
dc.subjectCHROMATIN STRUCTURE
dc.subjectNON-B DNA
dc.subjectRNA POLYMERASE II ELONGATION
dc.titleChromatin, DNA structure and alternative splicing
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:ar-repo/semantics/artículo
dc.typeinfo:eu-repo/semantics/publishedVersion


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