dc.creatorBrunello, Franco Gino
dc.creatorRey, Rodolfo Alberto
dc.date.accessioned2022-09-09T10:24:56Z
dc.date.accessioned2022-10-15T06:13:07Z
dc.date.available2022-09-09T10:24:56Z
dc.date.available2022-10-15T06:13:07Z
dc.date.created2022-09-09T10:24:56Z
dc.date.issued2021-08
dc.identifierBrunello, Franco Gino; Rey, Rodolfo Alberto; AMH and AMHR2 Involvement in Congenital Disorders of Sex Development; Karger; Sexual Development; 8-2021; 1-9
dc.identifier1661-5425
dc.identifierhttp://hdl.handle.net/11336/168064
dc.identifierCONICET Digital
dc.identifierCONICET
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/4353919
dc.description.abstractAnti-Müllerian hormone (AMH) is one of the two testicular hormones involved in male development of the genitalia during fetal life. When the testes differentiate, AMH is secreted by Sertoli cells and binds to its specific receptor type II (AMHR2) on the Müllerian ducts, inducing their regression. In the female fetus, the lack of AMH allows the Müllerian ducts to form the Fallopian tubes, the uterus and the upper part of the vagina. The human AMH gene maps on 19p13.3 and consists of 5 exons and 4 introns spanning 2764 bp. The AMHR2 gene maps on 12q13.13, consists of 11 exons and is 7817-bp long. Defects in the AMH pathway are the underlying aetiology of a subgroup of disorders of sex development (DSD) in 46,XY patients. The condition is known as the persistent Müllerian ducts syndrome (PMDS), characterised by the existence of a uterus and Fallopian tubes in a boy with normally virilised external genitalia. Approximately 200 cases of patients with PMDS have been reported to date with clinical, biochemical and molecular genetic characterisation. An updated review is provided in this paper. With highly sensitive techniques AMH and AMHR2 expression has also been detected In other tissues, and massive sequencing technologies have unveiled variants in AMH and AMHR2 genes in hitherto unsuspected conditions.
dc.languageeng
dc.publisherKarger
dc.relationinfo:eu-repo/semantics/altIdentifier/url/https://www.karger.com/Article/FullText/518273
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1159/000518273
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectFALLOPIAN TUBES
dc.subjectTESTIS
dc.subjectOVARY
dc.subjectPERSISTENT MULLERIAN DUCT SYNDROME
dc.titleAMH and AMHR2 Involvement in Congenital Disorders of Sex Development
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:ar-repo/semantics/artículo
dc.typeinfo:eu-repo/semantics/publishedVersion


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