dc.creator | Parisi, Gustavo Daniel | |
dc.creator | Zea, Diego Javier | |
dc.creator | Monzón, Alexander | |
dc.creator | Marino Buslje, Cristina | |
dc.date.accessioned | 2021-06-11T12:47:26Z | |
dc.date.accessioned | 2022-10-15T06:11:19Z | |
dc.date.available | 2021-06-11T12:47:26Z | |
dc.date.available | 2022-10-15T06:11:19Z | |
dc.date.created | 2021-06-11T12:47:26Z | |
dc.date.issued | 2015-03 | |
dc.identifier | Parisi, Gustavo Daniel; Zea, Diego Javier; Monzón, Alexander; Marino Buslje, Cristina; Conformational diversity and the emergence of sequence signatures during evolution; Current Biology; Current Opinion In Structural Biology; 32; 3-2015; 58-65 | |
dc.identifier | 0959-440X | |
dc.identifier | http://hdl.handle.net/11336/133664 | |
dc.identifier | 1879-033X | |
dc.identifier | CONICET Digital | |
dc.identifier | CONICET | |
dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/4353747 | |
dc.description.abstract | Proteins' native structure is an ensemble of conformers in equilibrium, including all their respective functional states and intermediates. The induced-fit first and the pre-equilibrium theories later, described how structural changes are required to explain the allosteric and cooperative behaviours in proteins, which are key to protein function. The conformational ensemble concept has become a key tool in explaining an endless list of essential protein properties such as function, enzyme and antibody promiscuity, signal transduction, protein-protein recognition, origin of diseases, origin of new protein functions, evolutionary rate and order-disorder transitions, among others. Conformational diversity is encoded by the amino acid sequence and such a signature can be evidenced through evolutionary studies as evolutionary rate, conservation and coevolution. | |
dc.language | eng | |
dc.publisher | Current Biology | |
dc.relation | info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0959440X15000147 | |
dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.sbi.2015.02.005 | |
dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | |
dc.rights | info:eu-repo/semantics/restrictedAccess | |
dc.subject | PROTEINS | |
dc.subject | EVOLUTION | |
dc.subject | CONFORMATIONAL DIVERSITY | |
dc.subject | COEVOLUTION | |
dc.title | Conformational diversity and the emergence of sequence signatures during evolution | |
dc.type | info:eu-repo/semantics/article | |
dc.type | info:ar-repo/semantics/artículo | |
dc.type | info:eu-repo/semantics/publishedVersion | |