dc.creatorVeleiro, Adriana Silvia
dc.creatorBurton, Gerardo
dc.date.accessioned2019-03-22T17:07:23Z
dc.date.accessioned2022-10-15T05:51:32Z
dc.date.available2019-03-22T17:07:23Z
dc.date.available2022-10-15T05:51:32Z
dc.date.created2019-03-22T17:07:23Z
dc.date.issued2009-12
dc.identifierVeleiro, Adriana Silvia; Burton, Gerardo; Structure-activity relationships of neuroactive steroids acting on the GABAA receptor; Bentham Science Publishers; Current Medicinal Chemistry; 16; 4; 12-2009; 455-472
dc.identifier0929-8673
dc.identifierhttp://hdl.handle.net/11336/72302
dc.identifierCONICET Digital
dc.identifierCONICET
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/4351878
dc.description.abstractThe term "neuroactive steroid" (NAS) refers to steroids which, independent of their origin, are capable of modifying neural activities. These steroids positively or negatively modulate the function of members of the ligand-gated ion channel superfamily. Those with positive allosteric actions on the γ-amino butyric acid type A receptor (GABAA receptor) have been shown to be potent anticonvulsants, anxiolytics, and antistress agents and to possess sedative, hypnotic, and anesthetic activities. New types of neuroactive steroids have been widely sought and structural modifications of the naturally occurring metabolites allopregnanolone, pregnanolone and allotetrahydrodeoxycorticosterone, have been examined in the light of the vast family of GABA receptor subtypes within the brain. Here we review the structure-activity relationship (SAR) of neuroactive steroid analogues obtained by modification of the steroid nucleus, including substitutions at the A, B, C, and D rings and the side chain, with emphasis on the different pharmacophores proposed. © 2009 Bentham Science Publishers Ltd.
dc.languageeng
dc.publisherBentham Science Publishers
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.2174/092986709787315522
dc.relationinfo:eu-repo/semantics/altIdentifier/url/http://www.eurekaselect.com/68515/article
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectANTICONVULSANT
dc.subjectGABAA RECEPTOR
dc.subjectNEUROACTIVE STEROIDS
dc.subjectNEUROSTEROIDS
dc.subjectSTRUCTURE-ACTIVITY RELATIONSHIP
dc.titleStructure-activity relationships of neuroactive steroids acting on the GABAA receptor
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:ar-repo/semantics/artículo
dc.typeinfo:eu-repo/semantics/publishedVersion


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