dc.creator | Capiglioni, Milena Sofía | |
dc.creator | Zwick, Analía Elizabeth | |
dc.creator | Jiménez, Pablo Javier | |
dc.creator | Álvarez, Gonzalo A. | |
dc.date.accessioned | 2021-12-03T15:21:12Z | |
dc.date.accessioned | 2022-10-15T05:23:49Z | |
dc.date.available | 2021-12-03T15:21:12Z | |
dc.date.available | 2022-10-15T05:23:49Z | |
dc.date.created | 2021-12-03T15:21:12Z | |
dc.date.issued | 2021-01 | |
dc.identifier | Capiglioni, Milena Sofía; Zwick, Analía Elizabeth; Jiménez, Pablo Javier; Álvarez, Gonzalo A.; Noninvasive quantitative imaging of selective microstructure sizes via magnetic resonance; American Physical Society; Physical Review Applied; 15; 1; 1-2021; 1-11 | |
dc.identifier | 2331-7019 | |
dc.identifier | http://hdl.handle.net/11336/148130 | |
dc.identifier | CONICET Digital | |
dc.identifier | CONICET | |
dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/4349376 | |
dc.description.abstract | Extracting quantitative microstructure information of living tissue by noninvasive imaging is an outstanding challenge for understanding disease mechanisms and allowing early stage diagnosis of pathologies. Magnetic resonance imaging (MRI) is a promising and widely used technique to pursue this goal, but still provides low resolution to reveal microstructure details. We here report on a method to produce images of filtered microstructure sizes based on selectively probing the nuclear-spin dephasing induced by the molecular diffusion within specific tissue compartments. The microstructure-size filter relies on suitable dynamical control of nuclear spins that sense magnetization "decay shifts"rather than the commonly used spin-echo decay rates. The feasibility and performance of the method are illustrated with proof-of-principle experiments and simulations on typical size distributions of white matter in the mouse brain. These results position spin-echo decay shifts as a promising MRI tool as they could offer the ability to perform noninvasive histology without assuming a microstructure distribution model. This sets a step towards unraveling diagnostic information based on microscopic parameters of biological tissue. | |
dc.language | eng | |
dc.publisher | American Physical Society | |
dc.relation | info:eu-repo/semantics/altIdentifier/url/https://journals.aps.org/prapplied/abstract/10.1103/PhysRevApplied.15.014045 | |
dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1103/PhysRevApplied.15.014045 | |
dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.subject | MRI | |
dc.subject | NMR | |
dc.subject | Difussion Molecular | |
dc.subject | Tissue Microstructure | |
dc.title | Noninvasive quantitative imaging of selective microstructure sizes via magnetic resonance | |
dc.type | info:eu-repo/semantics/article | |
dc.type | info:ar-repo/semantics/artículo | |
dc.type | info:eu-repo/semantics/publishedVersion | |